Patents Assigned to Applied Biosystems, Incorporated
  • Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof
    Patent number: 4757141
    Abstract: The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: July 12, 1988
    Assignee: Applied Biosystems, Incorporated
    Inventors: Steven Fung, Sam L. Woo, Lloyd M. Smith