Patents Assigned to Applied Molecular Evolution, Inc. c/o Eli Lilly and Company Patent Division
  • Butyrylcholinesterase Variants that Alter the Activity of Chemotherapeutic Agents
    Publication number: 20080213281
    Abstract: The invention provides a butyrylchinesterase variant, a method of converting a camptothecin derivative to a topoisomerase inhibitor by contacting the camptothecin derivative with a butyrylcholinesterase variant and a method of treating cancer by administering to an individual an effective amount a butyrylcholinesterase variant exhibiting increased capability to convert a camptothecin derivative to a topoisomerase inhibitor compared to butyrylcholinesterase.
    Type: Application
    Filed: December 4, 2003
    Publication date: September 4, 2008
    Applicant: Applied Molecular Evolution, Inc. c/o Eli Lilly and Company Patent Division
    Inventors: Jeffrey D. Watkins, James D. Pancock