Abstract: There is disclosed a novel genus of small peptides, much smaller than human TGF?, was discovered as having TGF? biological activity and therefore are useful as pharmacologic agents for the same indications as full length TGF? polypeptide. There is further disclosed that TGF? and consequently the genus of small peptides disclosed herein, was found to have therapeutic activity to stimulate hematopoiesis in patients undergoing cytotoxic cancer chemotherapy and to act as a cytoprotective agent to protect a patient undergoing cancer cytotoxic therapy from gastrointestinal (GI) side effects, such as mucositis and otherwise support the barrier function of the GI tract when it is harmed by cytotoxic therapy.
Type:
Grant
Filed:
July 16, 2004
Date of Patent:
April 29, 2008
Assignee:
Applied Protein Sciences LLC
Inventors:
Daniel R Twardzik, Stefan Paskell, Thomas S Felker
Abstract: Disclosed are TGF-? polypeptides, related polypeptides, fragments and mimetics thereof useful in stimulating stem cell or precursor cell proliferation, migration and differentiation. The methods of the invention are useful to treat tissue injury as well as expand stem cell populations in, or obtained from, gastrointestinal, musculoskeletal, urogenital, neurological and cardiovascular tissues. The methods include ex vivo and in vivo applications.
Type:
Grant
Filed:
January 15, 2002
Date of Patent:
February 12, 2008
Assignee:
Applied Protein Sciences, LLC
Inventors:
Daniel R. Twardzik, Andre Pernet, Thomas S. Felker, Stefan Paskell