Patents Assigned to Applied Spectral Imaging Ltd.
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Patent number: 11012643Abstract: A spectral imaging system comprises: a sequential optical system providing a temporal sequence of output light beams describing the scene; a color imager receiving the output light beams and responsively generating, for each output light beam, an image signal that is spatially resolved into a plurality of color channels. The system can also comprise an image processor that collectively process the image signals to construct a spectral image of the scene.Type: GrantFiled: December 15, 2016Date of Patent: May 18, 2021Assignee: Applied Spectral Imaging Ltd.Inventor: Nir Katzir
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Patent number: 9915565Abstract: A method of calibrating a spectral imaging system is disclosed. The spectral imaging system comprises an interferometer having a beam splitter and at least a first reflector and a second reflector. The method comprises: obtaining data pertaining to an interference pattern model, operating the spectral imaging system to provide an interference pattern of a received light beam, and varying a relative orientation between at least two of: the beam splitter, the first reflector and the second reflector, until the interference pattern of the input light beam substantially matches the interference pattern model.Type: GrantFiled: October 24, 2013Date of Patent: March 13, 2018Assignee: Applied Spectral Imaging Ltd.Inventor: Nir Katzir
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Patent number: 9133506Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.Type: GrantFiled: January 9, 2007Date of Patent: September 15, 2015Assignee: Applied Spectral Imaging Ltd.Inventors: Nir Katzir, Tsafrir Kolatt, Irit Bar-Am
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Publication number: 20100177942Abstract: According to an aspect of some embodiments of the present invention there is provided a method of analyzing imagery data pertaining to a biological sample. the method comprises: identifying structures of biological elements in the imagery data based on achromatic intensity values of the imagery data, and displaying the imagery data as a color-coded image.Type: ApplicationFiled: January 14, 2010Publication date: July 15, 2010Applicant: Applied Spectral Imaging Ltd.Inventors: Tsafrir KOLATT, Elior Shenhav
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Publication number: 20090304244Abstract: A method for presenting at least one structure of a histological specimen. The method comprises providing a plurality of images of a plurality of sections of a single histological specimen having a plurality of structures, segmenting a plurality of segments of the plurality of structures in each the image, associating among respective the segments of a common structure of the plurality of structures, and presenting the association in relation to at least some of the plurality of images.Type: ApplicationFiled: April 10, 2009Publication date: December 10, 2009Applicant: Applied Spectral Imaging Ltd.Inventors: Tsafrir Kolatt, Eldad Klaiman
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Publication number: 20090048785Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.Type: ApplicationFiled: January 9, 2007Publication date: February 19, 2009Applicant: Applied Spectral Imaging Ltd.Inventors: Nir Katzir, Tsafrir Kolatt, Irit Bar-Am
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Publication number: 20070135999Abstract: A method for characterizing a stained pathological specimen is disclosed. The method comprises obtaining an image of the specimen, classifying the picture-elements of the image into classification groups, and using the classification groups to define at least one set of picture-elements corresponding to at least one tissue region of the pathological specimen. The method further comprises applying, on each set of picture-elements, at least one set-operator so as to characterize the tissue regions according to image data and spatial characteristics of the set.Type: ApplicationFiled: July 5, 2006Publication date: June 14, 2007Applicant: Applied Spectral Imaging Ltd.Inventor: Tsafrir Kolatt
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Patent number: 6690817Abstract: A method of spectral-morphometric analysis of biological samples, the biological samples including substantially constant components and suspected variable components, the method is effected by following the steps of (a) using a spectral data collection device for collecting spectral data of picture elements of the biological samples; (b) defining a spectral vector associated with picture elements representing a constant component of at least one of the biological samples; (c) using the spectral vector for defining a correcting function being selected such that when operated on spectral vectors associated with picture elements representing other constant components, spectral vectors of the other constant components are modified to substantially resemble the spectral vector; (d) operating the correcting function on spectral vectors associated with at least the variable components for obtaining corrected spectral vectors thereof; and (e) classifying the corrected spectral vectors into classification groups.Type: GrantFiled: September 18, 1998Date of Patent: February 10, 2004Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Robert A. Buckwald, Nissim Ben-Yosef
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Publication number: 20030215791Abstract: A method of detecting the presence, absence and/or level of a plurality of analytes-of-interest in a sample, the method comprisES: (a) providing a plurality of objects, each of the plurality of objects having a predetermined, measurable and different imagery characteristic, and further having a predetermined and specific affinity to one analyte of the plurality of analytes-of-interest, each the imagery characteristic corresponding to one the predetermined specific affinity, hence each the imagery characteristic corresponds to one analyte of the plurality of analytes-of interest; (b) providing at least one affinity moiety having a predetermined and specific affinity or predetermined and specific affinities to the plurality of analytes-of-interest, each the affinity moiety having a predetermined, measurable response to light; (c) combining the objects, the at least one affinity moiety and the sample under conditions for affinity binding; and (d) simultaneously determining, for each object of the plurality of obType: ApplicationFiled: October 23, 2002Publication date: November 20, 2003Applicant: Applied Spectral Imaging Ltd.Inventors: Yuval Garini, Nir Katzir, Irit Bar-Am, Uri Milman, Eli Horn, Yacov Malinovich, Terry Hammill, Vladimir Cherepakhin
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Patent number: 6556853Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.Type: GrantFiled: November 20, 1998Date of Patent: April 29, 2003Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Michael Adel, Robert A. Buckwald, Eli Horn
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Patent number: 6552794Abstract: A light reflecting article is disclosed. The light reflecting article comprises a sample carrying article layered with a light reflecting layer. The light reflecting layer serves for allowing an optical collection and detection system to collect both luminescent light emitted from a sample positioned on the light reflecting article in a direction of the optical collection and detection system, as well as luminescent light emitted from the sample in a direction away from the optical collection and detection system and reflected in the direction of the optical collection and detection system via the light reflecting layer, thereby increasing a sensitivity of luminescent light detection.Type: GrantFiled: April 4, 2001Date of Patent: April 22, 2003Assignee: Applied Spectral Imaging Ltd.Inventor: Yuval Garini
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Publication number: 20020176084Abstract: A light reflecting article is disclosed. The light reflecting article comprises a sample carrying article layered with a light reflecting layer. The light reflecting layer serves for allowing an optical collection and detection system to collect both luminescent light emitted from a sample positioned on the light reflecting article in a direction of the optical collection and detection system, as well as luminescent light emitted from the sample in a direction away from the optical collection and detection system and reflected in the direction of the optical collection and detection system via the light reflecting layer, thereby increasing a sensitivity of luminescent light detection.Type: ApplicationFiled: April 4, 2001Publication date: November 28, 2002Applicant: Applied Spectral Imaging Ltd.Inventor: Yuval Garini
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Publication number: 20020141624Abstract: A synchronizing imaging apparatus to obtain images from an object undergoing variations according to a cycle with the apparatus comprising an acquisition device to acquire a plurality of pre-images at respective phases over each one of a plurality of cycles, and an image matcher to match together the pre-images from different ones of said cycles according to respective phases within said cycles, to create a representation of said cycle.Type: ApplicationFiled: May 28, 2002Publication date: October 3, 2002Applicant: Applied Spectral Imaging Ltd.Inventors: Amir Gil, Tamir Gil, Eli Horn, Yuval Garini
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Publication number: 20020099295Abstract: A method of functional brain mapping of a subject is disclosed. The method is effected by (a) illuminating an exposed cortex of a brain or portion thereof of the subject with incident light; (b) acquiring a reflectance spectrum of each picture element of at least a portion of the exposed cortex of the subject; (c) stimulating the brain of the subject; (d) during or after step (c) acquiring at least one additional reflectance spectrum of each picture element of at least the portion of the exposed cortex of the subject; and (e) generating an image highlighting differences among spectra of the exposed cortex acquired in steps (b) and (d), so as to highlight functional brain regions. Algorithms for calculating oxygen saturation and blood volume maps which can be used to practice the method are also disclosed. Systems for practicing the method are also disclosed.Type: ApplicationFiled: February 6, 2001Publication date: July 25, 2002Applicant: Applied Spectral Imaging Ltd.Inventors: Amir Gil, Tamir Gil, Eli Horn, Yuval Garini
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Patent number: 6419361Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.Type: GrantFiled: January 3, 2001Date of Patent: July 16, 2002Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Michael Adel, Robert A. Buckwald
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Patent number: 6276798Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color or intensity according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.Type: GrantFiled: May 10, 1999Date of Patent: August 21, 2001Assignee: Applied Spectral Imaging, Ltd.Inventors: Tamir Gil, Dario Cabib, Mike Adel, Robert A. Buckwald, Eli Horn
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Patent number: 6198532Abstract: A spectral bio-imaging method for enhancing pathologic, physiologic, metabolic and health related spectral signatures of an eye tissue, the method comprising the steps of (a) providing an optical device for eye inspection being optically connected to a spectral imager; (b) illuminating the eye tissue with light via the iris, viewing the eye tissue through the optical device and spectral imager and obtaining a spectrum of light for each pixel of the eye tissue; and (c) attributing each of the pixels a color according to its spectral signature, thereby providing an image enhancing the spectral signatures of the eye tissue.Type: GrantFiled: October 1, 1997Date of Patent: March 6, 2001Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Michael Adel, Robert A. Buckwald
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Patent number: 6165734Abstract: A method of in situ analysis of a biological sample comprising the steps of (a) staining the biological sample with N stains of which a first stain is selected from the group consisting of a first immunohistochemical stain, a first histological stain and a first DNA ploidy stain, and a second stain is selected from the group consisting of a second immunohistochemical stain, a second histological stain and a second DNA ploidy stain, with provisions that N is an integer greater than three and further that (i) if the first stain is the first immunohistochemical stain then the second stain is either the second histological stain or the second DNA ploidy stain; (ii) if the first stain is the first histological stain then the second stain is either the second immunohistochemical stain or the second DNA ploidy stain; whereas (iii) if the first stain is the first DNA ploidy stain then the second stain is either the second immunohistochemical stain or the second histological stain; and (b) using a spectral data collecType: GrantFiled: November 20, 1998Date of Patent: December 26, 2000Assignee: Applied Spectral Imaging Ltd.Inventors: Yuval Garini, George McNamara, Dirk Soenksen, Dario Cabib, Robert A Buckwald
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Patent number: 6142629Abstract: A device and method for spectral imaging of an object. A plurality of sets of narrow-band light sources such as LEDs are provided. Each set emits illumination radiation in a different narrow spectral band. Each set is activated sequentially to illuminate the object. Light reflected from the object or transmitted by the object is focused on a detector array to image the object. Narrower illumination bands are provided by dispersing the emitted light using a dispersive optical element such as a diffraction grating. Alternatively; selected sets or subsets are activated simultaneously with duty cycles that emulate a preselected spectral distribution. For imaging ocular fundus tissue, the illumination light is shaped into an annular beam by an appropriately shaped waveguide.Type: GrantFiled: August 30, 1998Date of Patent: November 7, 2000Assignee: Applied Spectral Imaging Ltd.Inventors: Michael E. Adel, Dario Cabib, David Wine
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Patent number: 6088099Abstract: A method for spatial registration and spectral correction for interferometer based spectral imaging which can be used to obtain spectral images of a moving object, the method comprising the steps of (a) using an interferometer based spectral imager for acquiring spatial and spectral information of the moving object; and (b) correcting the spatial and spectral information for movements of the moving object via a spatial registration and spectral correction procedures for obtaining corrected spatial and spectral information.Type: GrantFiled: June 19, 1998Date of Patent: July 11, 2000Assignee: Applied Spectral Imaging Ltd.Inventors: Dario Cabib, Robert A. Buckwald