Abstract: Devices and methods for edema management, e.g., reducing edema, are disclosed. A treatment device may include a chamber defining a treatment space, the chamber being fabricated from a substantially impermeable material and configured to conform to the shape of the periphery, an inner surface of the chamber including a plurality of surface patterns, the chamber having a sealing portion at a base; and at least one conduit connected to the chamber and in fluid communication with the treatment space so as to enable the application of a negative pressure to the treatment space. The treatment device may be configured for reducing edema at a target site on a subject. The treatment device may be further configured for edema management, e.g., reducing edema, of at least one breast, e.g., both breasts, of a subject.

Abstract: The present invention provides a device for wound treatment, comprising a chamber that includes an inner surface and defines a treatment space, the chamber being made of a flexible, impermeable material. The device further includes a plurality of structures configured to exert mechanical stress on a wound, the plurality of structures intruding from the inner surface of the chamber into the treatment space. The device further includes a tube having a first end connected to the chamber, the tube being in fluid communication with the treatment space so as to enable at least one selected from the group of applying negative pressure to the treatment space and applying a therapeutic agent.

Abstract: Devices and methods for wound treatment are disclosed. A chamber may define a treatment space having an interior engineered surface including a plurality of structures configured to provide pathways for the distribution of negative pressure and to exert mechanical stress on a wound. In some specific embodiments, the devices and methods may treat wounds on the head, neck, and face. One or more tubes may be in fluid communication with the treatment space to facilitate the application of negative pressure, the introduction of therapeutic agents, and the removal of wound material.

Abstract: The present invention provides a device for wound treatment, comprising a chamber that includes an inner surface and defines a treatment space, the chamber being made of a flexible, impermeable material. The device further includes a plurality of structures configured to exert mechanical stress on a wound, the plurality of structures intruding from the inner surface of the chamber into the treatment space. The device further includes a tube having a first end connected to the chamber, the tube being in fluid communication with the treatment space so as to enable at least one selected from the group of applying negative pressure to the treatment space and applying a therapeutic modality.