Patents Assigned to APSE, LLC
  • IN VIVO PRODUCTION OF LONG DOUBLE STRANDED RNA UTILIZING VLPS
    Publication number: 20180291066
    Abstract: Methods and compositions for producing, isolating and purifying virus-like particles (VLPs) containing long sense and antisense RNA molecules, including RNA molecules predicted to fold into double-stranded regions longer than the inner diameter of the VLP capsids are disclosed.
    Type: Application
    Filed: May 9, 2016
    Publication date: October 11, 2018
    Applicant: APSE, LLC
    Inventors: Juan Pedro Humberto ARHANCET, PATRICK D. MCLAUGHLIN
  • METHODS AND COMPOSITIONS COMPRISING APSE KNOTS
    Publication number: 20180265868
    Abstract: The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming pseudoknots and being encapsidated in Virus Like Particles having higher insect control efficacy than previously described RNA molecules.
    Type: Application
    Filed: September 30, 2016
    Publication date: September 20, 2018
    Applicant: APSE, LLC
    Inventor: Juan P. H. ARHANCET
  • COMPOSITIONS AND METHODS USING CAPSIDS RESISTANT TO HYDROLASES
    Publication number: 20160208221
    Abstract: Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.
    Type: Application
    Filed: September 12, 2014
    Publication date: July 21, 2016
    Applicant: APSE, LLC
    Inventors: Juan Pedro Humberto ARHANCET, Neena SUMMERS, Henry HUANG
  • COMPOSITIONS AND METHODS USING CAPSIDS RESISTANT TO HYDROLASES
    Publication number: 20160177299
    Abstract: Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNAs and shRNAs, miRNAs, messenger RNAs, small peptides and bioactive molecules.
    Type: Application
    Filed: June 5, 2014
    Publication date: June 23, 2016
    Applicant: APSE LLC
    Inventors: Juan Pedro Humberto ARHANCET, JUAN P. ARHANCET, Kimberly DELANEY, Kathleen B. HALL, Neena SUMMERS, Edward OATES
  • Process for purifying VLPs
    Patent number: 9181531
    Abstract: Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: November 10, 2015
    Assignee: APSE, LLC
    Inventors: Juan Pedro Humberto Arhancet, Juan P. Arhancet, Kimberly Delaney, Kathleen B. Hall, Neena Summers
  • PROCESS FOR PURIFYING VLPS
    Publication number: 20140302593
    Abstract: Processes and compositions to produce, package, and purify virus like particles containing heterologous cargo molecules utilizing self assembling proteins and protease treatment coupled with simple precipitation and filtration methods are described.
    Type: Application
    Filed: May 16, 2014
    Publication date: October 9, 2014
    Applicant: APSE, LLC
    Inventors: Juan Pedro Humberto Arhancet, Juan P. Arhancet, Kimberly Delaney, Kathleen B. Hall, Neena Summers
  • PROCESSES USING VLPS WITH CAPSIDS RESISTANT TO HYDROLASES
    Publication number: 20130167267
    Abstract: Novel processes and compositions are described which use viral capsid proteins resistant to hydrolases to prepare virus-like particles to enclose and subsequently isolate and purify target cargo molecules of interest including nucleic acids such as siRNA's and shRNA's, and small peptides.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 27, 2013
    Applicant: APSE, LLC
    Inventor: Apse, LLC