Abstract: This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
Type:
Grant
Filed:
September 1, 2006
Date of Patent:
February 19, 2008
Assignee:
Apsinterm LLC
Inventors:
Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
Type:
Grant
Filed:
January 27, 2006
Date of Patent:
August 14, 2007
Assignee:
Apsinterm, LLC.
Inventors:
Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson
Abstract: This invention provides a method of preparing amine stereoisomers, which comprises stereoselectively reducing a sulfinylimine that bears on the sulfinyl group a residue of an alcohol, thiol or amine, or reacting a sulfinylimine stereoisomer that bears on the sulfinyl group a residue of an alcohol, thiol or amine with a source of a nucleophile, to afford a sulfinylamine stereoisomer, followed by contacting the sulfinylamine stereoisomer with a reagent suitable for the cleavage of a sulfur-nitrogen bond, to afford an amine stereoisomer. It also provides novel intermediates useful in the method, and the use of certain of the intermediates in the preparation of sulfoxide and sulfinylamine stereoisomers.
Type:
Grant
Filed:
April 7, 2003
Date of Patent:
October 31, 2006
Assignee:
Apsinterm, LLC
Inventors:
Zhengxu Han, Dhileepkumar Krishnamurthy, Chris Hugh Senanayake, Zhi-Hui Lu
Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.
Type:
Grant
Filed:
April 12, 2002
Date of Patent:
June 20, 2006
Assignee:
Apsinterm LLC
Inventors:
Chris Hugh Senanayake, Zhengxu Han, Dhileepkumar Krishnamurthy, Derek Pflum, Harold Scott Wilkinson