Patents Assigned to APTAH BIO, INC.
  • Polynucleotide compositions and methods for gene expression regulations
    Patent number: 11946050
    Abstract: This disclosure concerns an engineered polynucleotide that interacts with a pre-mRNA and a spliceosome to regulate gene expression. The engineered polynucleotide may have stem-loop structure that recruits the spliceosome and targeting sequences that are complementary to a target sequence at an exon-intron splice junction and may include nucleotides with 2? modifications and phorphorothioate linkages.
    Type: Grant
    Filed: July 18, 2022
    Date of Patent: April 2, 2024
    Assignee: APTAH BIO, INC.
    Inventor: Caio Bruno Quinta De Souza Leal