Patents Assigned to APTUIT (VERONA) SRL
  • Inhibitors of complement factors and uses thereof
    Patent number: 11814404
    Abstract: Disclosed are compounds of formula I and II and pharmaceutically acceptable salts thereof. Also disclosed are methods of treating a neurodegenerative disorder, an inflammatory disease, an autoimmune disease, an ophthalmic disease or a metabolic disorder using the compounds disclosed herein.
    Type: Grant
    Filed: July 19, 2021
    Date of Patent: November 14, 2023
    Assignees: ANNEXON, INC., APTUIT (VERONA) SRL
    Inventors: Dean R. Artis, Colin P. Leslie, Luca B. Mileo, Claudia Beato, Federico Sorana, Bruno Di Guglielmo, Chiara Padroni
  • Broad spectrum antivirulence, anti-persistence compounds
    Patent number: 11731946
    Abstract: The present application provides malonamide compounds, and derivatives thereof (e.g., N-aryl malonamides (NAM), acetamides, oxalamides, and the like), that are useful, for example, for the treatment of acute, chronic/persistent, and/or relapsing infections. Pharmaceutical compositions, methods of treating diseases (e.g., bacterial infections), and methods of reducing bacterial virulence are also provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: August 22, 2023
    Assignees: The General Hospital Corporation, Aptuit (Verona) SRL, An Evotec Company
    Inventors: Laurence Rahme, Francois Lepine, Damien Maura, Carmela Napolitano, Antonio Felici, Michele Negri, Stefano Fontana, Daniele Andreotti