Abstract: The present disclosure relates to crystallizing a chemical substance(s) using ultrasound. Methods are provided for screening a chemical substance according to its solid forms by using ultrasound to generate new or unusual solid forms. Methods are also provided for crystallizing a chemical substance by novel techniques that include sonication. The present disclosure also relates to cocrystallization using ultrasound. Methods are provided for preparing cocrystals of an active agent and a guest by sonicating and crystallizing. Methods are also provided for screening a sample according to solid state phases (such as cocrystals and salts) and include generating a cocrystal from the sample using ultrasound.
Type:
Grant
Filed:
September 22, 2010
Date of Patent:
December 30, 2014
Assignee:
Aptuit (West Lafayette), LLC
Inventors:
Scott L. Childs, Patricia M. Mougin-Andres, Barbara C. Stahly
Abstract: The disclosure relates to devices for creating a low-background scattering environment proximate to the stage of an x-ray diffractometer, x-ray diffractometer systems comprising the same, and methods for collecting x-ray diffraction data.
Type:
Grant
Filed:
November 22, 2011
Date of Patent:
May 27, 2014
Assignee:
Aptuit (West Lafayette), LLC
Inventors:
Richard B. McClurg, Paul J. Schields, Rex A. Shipplett, II, Gerald Wetli
Abstract: The methods of the invention determine the unit cell parameters of a crystalline solid form using diffraction data and applying an algorithm. Using the algorithm, the unit cell parameters may be determined, which may allow one to distinguish between different crystalline solid forms of a substance.
Abstract: Disclosed are processes for preparing cocrystals, including processes for scaling up of cocrystal formation, as well as scalable processes for preparing cocrystals. Also disclosed are processes for scaled-up preparation of pterostilbene, progesterone, p-coumaric, and minoxidil cocrystals. Minoxidil cocrystals, such as minoxidil:benzoic acid 1:1 monohydrate cocrystals are also disclosed herein.
Abstract: Methods for preparing mannitol modification III are described herein. The methods relate to preparing solutions of mannitol in a suitable solvent and an auxiliary agent and solidifying from the solutions mannitol of modification III.
Type:
Grant
Filed:
May 21, 2008
Date of Patent:
March 5, 2013
Assignee:
Aptuit (West Lafayette), LLC
Inventors:
Jan-Olav Henck, Mark C. Andres, Linda J. McCausland
Abstract: The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.
Abstract: The disclosure relates to devices for creating a low-background scattering environment proximate to the stage of an x-ray diffractometer, x-ray diffractometer systems comprising the same, and methods for collecting x-ray diffraction data.
Type:
Application
Filed:
November 22, 2011
Publication date:
June 21, 2012
Applicant:
APTUIT (West Lafayette) LLC
Inventors:
Richard B. MCCLURG, Paul J. SCHIELDS, Rex A. SHIPPLETT, II, Gerald WETLI