Abstract: A formulation contains at least one natural Cannabis material, at least one solvent, and at least one stabilizer. The formulation is a liquid suspension having a particle size (D90) of below 500 nm. The formulation can be used in the treatment of a disease.

Abstract: A computer-implemented method can be used for monitoring spray delivery of drug-containing liquid for remedying a discomfort. The method involves a) receiving first input data, the first input data containing a number of delivered puffs as detected by a counter of a spray device during an intake period, b) receiving second input data containing user state data representative of self-reported perceived discomfort level, particularly pain level, and/or self-reported perceived side effect severity during the intake period, the user state data being obtained from a user input via a user interface of an application, c) determining, based at least on the first input data and the second input data, a suggested number of delivered puffs for an upcoming intake period, and d) outputting, via the user interface, user instructions indicating the suggested number of delivered puffs.

Abstract: The present disclosure relates to a method for the preparation of a nanosuspension of at least one natural material, wherein the method comprises the steps of (a) providing at least one natural material having a particle size (D90) of less than 320 ?m; (b) dispersing said at least one natural material of step (a) in a solvent; and (c) milling the dispersion of step (b) to a particle size (D90) of below 1000 nm. The nanosuspension is useful for the preparation of a medicament.

Abstract: The present disclosure relates to a method for the preparation of a nanosuspension of at least one natural material, wherein the method comprises the steps of (a) providing at least one natural material having a particle size (D90) of less than 320 ?m; (b) dispersing said at least one natural material of step (a) in a solvent; and (c) milling the dispersion of step (b) to a particle size (D90) of below 1000 nm. The nanosuspension is useful for the preparation of a medicament.