Abstract: Systems and methods for coagulation optimization may include a control system deployed at the water treatment plant operating with a computing system executing various control model(s). The computing system may receive data including one or more water quality metrics and a settled turbidity setpoint of output water. The computing system may also receive a manual input corresponding to a dose of coagulant received during a manual override (e.g., at a first time instance). The control model(s) may determine the recommended dose of coagulant, while accounting for the manual input and the one or more metrics. When the control system has a handover from manual mode to automatic mode, the computing system may determine a recommended dose of coagulant based on the input data and the manual input. The computing system may transmit data corresponding to the recommended dose of coagulant to the control system of the water treatment plant.