Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.
Type:
Grant
Filed:
October 18, 2023
Date of Patent:
December 24, 2024
Assignee:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Keith Kendall, Dan Barber, Theresa Wood, Peter Boyd, John Maxwell
Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described, the prodrugs having a half-life of less than one minute, and the compositions having enhanced active component permeation properties are described.
Type:
Application
Filed:
January 16, 2024
Publication date:
May 9, 2024
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Stephanie Marie Varjan, Stephen Paul Wargacki
Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.
Type:
Application
Filed:
October 18, 2023
Publication date:
February 15, 2024
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Keith Kendall, Dan Barber, Theresa Wood, Peter Boyd, John Maxwell
Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described and the compositions having enhanced active component permeation properties are described as being administered with specific residence times.
Type:
Application
Filed:
June 14, 2023
Publication date:
January 18, 2024
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Stephanie Marie Varjan, Stephen Paul Wargacki
Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.
Type:
Application
Filed:
September 7, 2023
Publication date:
December 28, 2023
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Keith Kendall, Dan Barber, Theresa Wood, Peter Boyd, John Maxwell
Abstract: Systems and methods for making and delivering personalized, medically prescribed pharmaceuticals to an individual patient are described. Individual unit doses (IUDs) of medicine may be prepared specific to the individual in need of same, by using a system, which includes a networked control system in combination with manufacturing assemblies specific to the IUDs and delivering the medicine to the patient directly from the manufacturer.
Type:
Grant
Filed:
June 20, 2019
Date of Patent:
November 7, 2023
Assignee:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Keith Kendall, Dan Barber, Theresa Wood, Peter Boyd, John Maxwell
Abstract: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.
Type:
Application
Filed:
November 17, 2022
Publication date:
May 18, 2023
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Stephen Wargacki, Vincent J. Buono, Susan Shumard, Christopher James Santee
Abstract: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.
Type:
Application
Filed:
December 30, 2022
Publication date:
May 11, 2023
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Stephen Wargacki, Vincent J. Buono, Susan Shumard, Christopher James Santee
Abstract: An oral film in an individual unit dose for delivery of one or more actives is disclosed herein, the film having a precisely calculated and controlled active dissolution profile. A wide variety of actives may be used, including, for example, clobazam, diazepam, or riluzole. Also disclosed are methods of treating a variety of diseases and conditions, for example, epilepsy and seizures, by administering the oral film disclosed herein.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
January 3, 2023
Assignee:
Aquestive Therapeutics, Inc.
Inventors:
Alexander Mark Schobel, Stephen Wargacki, Vincent J. Buono, Susan Shumard, Christopher James Santee
Abstract: Pharmaceutical compositions of epinephrine and its prodrugs are described, the prodrugs having a half-life of less than one minute, and the compositions having enhanced active component permeation properties are described.
Type:
Application
Filed:
December 13, 2021
Publication date:
May 26, 2022
Applicant:
AQUESTIVE THERAPEUTICS, INC.
Inventors:
Alexander Mark Schobel, Stephanie Marie Varjan, Stephen Paul Wargacki
Abstract: Film products, especially suitable for oral delivery, which can be formed during manufacture in the form of large and/or heavy film strips or sheets and subsequently cut into uniform dosage units, each dosage unit being uniform in content and having distributed therein a linear polysaccharide, such as pullulan, a plasticizer, and an active component.
Type:
Application
Filed:
September 29, 2021
Publication date:
March 24, 2022
Applicant:
Aquestive Therapeutics, Inc.
Inventors:
Garry L. Myers, Michael Li, Beuford Arlie Bogue, Eric Dadey
Abstract: The present invention relates to methods and apparatuses for forming an active-containing film product, while significantly reducing the amount of wasted active material. The resulting product is an active-containing film product that meets the user's predetermined criteria of physical properties and is suitable for use.
Abstract: The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component, which includes polyethylene oxide optionally blended with hydrophilic cellulosic polymers. Desirably, the films also contain a pharmaceutical and/or cosmetic active agent with no more than a 10% variance of the active agent pharmaceutical and/or cosmetic active agent per unit area of the film.
Type:
Grant
Filed:
August 3, 2020
Date of Patent:
December 28, 2021
Assignee:
Aquestive Therapeutics, Inc.
Inventors:
Robert K. Yang, Richard C. Fuisz, Garry L. Myers, Joseph M. Fuisz