Patents Assigned to Arbor Biotechnologies, Inc.
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Patent number: 11946045Abstract: The present invention relates to variant polypeptides, methods of preparing the variant polypeptides, processes for characterizing the variant polypeptides, compositions and cells comprising the variant polypeptides, and methods of using the variant polypeptides. The invention further relates to complexes comprising the variant polypeptides, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.Type: GrantFiled: December 30, 2022Date of Patent: April 2, 2024Assignee: Arbor Biotechnologies, Inc.Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Lauren E. Alfonse, Anthony James Garrity
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Publication number: 20240102007Abstract: A gene editing system comprising: (a) a Type V CRISPR nuclease polypeptide or a first nucleic acid encoding the Type V CRISPR nuclease polypeptide; (b) a reverse transcriptase (RT) polypeptide or a second nucleic acid encoding the RT polypeptide; (c) a guide RNA (gRNA) or a third nucleic acid encoding the gRNA, wherein the gRNA comprises one or more binding sites recognizable by the Type V CRISPR nuclease (CRISPR nuclease binding sites) and a spacer sequence specific to a target sequence within a genomic site of interest, the target sequence being adjacent to a protospacer adjacent motif (PAM); and (d) a reverse transcription donor RNA (RT donor RNA) or a fourth nucleic acid encoding the RT donor RNA, wherein the RT donor RNA comprises a primer binding site (PBS) and a template sequence.Type: ApplicationFiled: June 1, 2022Publication date: March 28, 2024Applicant: Arbor Biotechnologies, Inc.Inventors: David A. Scott, Noah Michael Jakimo, Pratyusha Hunnewell, Fu-Kai Hsieh
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Patent number: 11939607Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting LDHA for use in genetic editing of the LDHA gene. Also provide herein are methods of using the gene editing system for introducing edits to the LDHA gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.Type: GrantFiled: November 4, 2022Date of Patent: March 26, 2024Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo, Sejuti Sengupta
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Patent number: 11912992Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: December 9, 2022Date of Patent: February 27, 2024Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: Shaorong Chong, Winston X Yan, David A. Scott, David R. Cheng, Pratyusha Hunnewell
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Publication number: 20240026351Abstract: The present invention relates to compositions comprising RNA guides targeting TRAC, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.Type: ApplicationFiled: October 29, 2021Publication date: January 25, 2024Applicant: Arbor Biotechnologies, Inc.Inventor: Quinton Norman Wessells
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Publication number: 20240011031Abstract: The present invention relates nucleases, processes for characterizing the nucleases, compositions comprising the nucleases, and methods of using the nucleases.Type: ApplicationFiled: August 17, 2021Publication date: January 11, 2024Applicant: Arbor Biotechnologies, Inc.Inventors: David A. Scott, David R. Cheng, Winston X. Yan, Tia M. Ditommaso
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Patent number: 11866746Abstract: The present invention relates to variant Cas12i4 polypeptides, methods of producing the variant Cas12i4 polypeptides, processes for characterizing the variant Cas12i4 polypeptides, cells comprising the variant Cas12i4 polypeptides, and methods of using the variant Cas12i4 polypeptides. The invention further relates to complexes comprising a variant Cas12i4 polypeptide and an RNA guide, methods of producing the complexes, processes for characterizing the complexes, cells comprising the complexes, and methods of using the complexes.Type: GrantFiled: December 30, 2022Date of Patent: January 9, 2024Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: Shaorong Chong, Wei-Cheng Lu, Brendan Jay Hilbert, Quinton Norman Wessells, Tia Marie Ditommaso, Anthony James Garrity
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Publication number: 20230399639Abstract: The present invention relates to compositions comprising RNA guides targeting B2M, processes for characterizing the compositions, cells comprising the compositions, and methods of using the compositions.Type: ApplicationFiled: October 29, 2021Publication date: December 14, 2023Applicant: Arbor Biotechnologies, Inc.Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie DiTommaso, Noah Michael Jakimo
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Gene editing systems comprising an RNA guide targeting hydroxyacid oxidase 1 (HAO1) and uses thereof
Patent number: 11821012Abstract: Provided herein are gene editing systems and/or compositions comprising RNA guides targeting HAO1 for use in genetic editing of the HAO1 gene. Also provide herein are methods of using the gene editing system for introducing edits to the HAO1 gene and/or for treatment of primary hyperoxaluria (PH), and processes for characterizing the gene editing system.Type: GrantFiled: November 4, 2022Date of Patent: November 21, 2023Assignee: Arbor Biotechnologies, Inc.Inventors: Quinton Norman Wessells, Jeffrey Raymond Haswell, Tia Marie Ditommaso, Noah Michael Jakimo, Sejuti Sengupta -
Patent number: 11795442Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: August 17, 2022Date of Patent: October 24, 2023Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: David A. Scott, David R. Cheng, Winston X. Yan, Tia M. DiTommaso
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Patent number: 11667904Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered Type III-E CRISPR-Cas systems, components, and methods for targeted modification of DNA, RNA, and protein substrates. Each system includes one or more protein components and one or more nucleic acid components that together target DNA, RNA, or protein substrates.Type: GrantFiled: April 29, 2020Date of Patent: June 6, 2023Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: David R. Cheng, David A. Scott, Winston X. Yan
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Patent number: 11643654Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: June 1, 2022Date of Patent: May 9, 2023Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: David R. Cheng, David A. Scott, Winston X. Yan
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Publication number: 20230048564Abstract: The present disclosure relates to systems, compositions and methods for modifying target nucleic acid sequences.Type: ApplicationFiled: July 22, 2022Publication date: February 16, 2023Applicant: Arbor Biotechnologies, Inc.Inventors: Noah Michael Jakimo, Chad David Torgerson, Kyle Edward Watters
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Patent number: 11453867Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: October 19, 2021Date of Patent: September 27, 2022Assignee: ARBOR BIOTECHNOLOGIES, Inc.Inventors: David A. Scott, David R. Cheng, Winston X. Yan, Tia M. DiTommaso
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Patent number: 11447771Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: October 20, 2021Date of Patent: September 20, 2022Assignee: ARBOR BIOTECHNOLOGIES, Inc.Inventors: David R. Cheng, David A. Scott, Winston X. Yan
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Patent number: 11168322Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of a nucleic acid.Type: GrantFiled: March 8, 2018Date of Patent: November 9, 2021Assignee: Arbor Biotechnologies, Inc.Inventors: David R. Cheng, David A. Scott, Winston X. Yan, Shaorong Chong
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Patent number: 11168324Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: December 31, 2020Date of Patent: November 9, 2021Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: Shaorong Chong, Winston X. Yan, David A. Scott, David R. Cheng, Pratyusha Hunnewell
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Publication number: 20210301288Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR-Cas systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: ApplicationFiled: December 28, 2018Publication date: September 30, 2021Applicants: ARBOR BIOTECHNOLOGIES, INC., ARBOR BIOTECHNOLOGIES, INC.Inventors: David R. Cheng, David A. Scott, Winston X. Yan
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Patent number: 10808245Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of nucleic acids such as DNA. Each system includes one or more protein components and one or more nucleic acid components that together target nucleic acids.Type: GrantFiled: November 11, 2019Date of Patent: October 20, 2020Assignee: ARBOR BIOTECHNOLOGIES, INC.Inventors: Shaorong Chong, Winston X. Yan, David A. Scott, David R. Cheng, Pratyusha Hunnewell
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Patent number: 10392616Abstract: The disclosure describes novel systems, methods, and compositions for the manipulation of nucleic acids in a targeted fashion. The disclosure describes non-naturally occurring, engineered CRISPR systems, components, and methods for targeted modification of a nucleic acid.Type: GrantFiled: March 8, 2018Date of Patent: August 27, 2019Assignee: Arbor Biotechnologies, Inc.Inventors: David R. Cheng, David A. Scott, Winston X. Yan, Shaorong Chong