Patents Assigned to ARBOR PHARMACEUTICALS, LLC
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Patent number: 11938111Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.Type: GrantFiled: December 15, 2021Date of Patent: March 26, 2024Assignee: ARBOR PHARMACEUTICALS, LLCInventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
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Patent number: 11850222Abstract: The present invention provides oral solutions containing sotalol hydrochloride which advantageously avoid swallowing while providing with improved stability. The present invention also relates to methods of using the oral solutions for treatment of diseases and disorders, such as delay in reoccurrence of atrial fibrillation/atrial flutter and/or ventricular arrhythmias.Type: GrantFiled: September 29, 2020Date of Patent: December 26, 2023Assignee: ARBOR PHARMACEUTICALS, LLCInventors: H. Greg Thomas, Jeffrey S. Kiel
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Patent number: 11413277Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.Type: GrantFiled: December 22, 2021Date of Patent: August 16, 2022Assignee: Arbor Pharmaceuticals, LLCInventor: Hugh Greg Thomas
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Patent number: 11229621Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.Type: GrantFiled: January 22, 2020Date of Patent: January 25, 2022Assignee: Arbor Pharmaceuticals, LLCInventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
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Patent number: 11229207Abstract: An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a shampoo-condition which comprises an effective amount of avermectin, solubilizers, suspending agents, preservatives, nonionic surfactants, humectants, a silicone compound, and water. Also disclosed are methods of using the topical formulations disclosed within this specification to treat either a susceptible or treatment-resistant strain of lice, as well as uses in the manufacture of a medicament for treating or preventing a lice infestation from a susceptible or treatment-resistant strain in a human patient.Type: GrantFiled: March 20, 2020Date of Patent: January 25, 2022Assignee: Arbor Pharmaceuticals, LLCInventors: Nicholas Spring, Garry T. Gwozdz
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Patent number: 11207306Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.Type: GrantFiled: December 20, 2019Date of Patent: December 28, 2021Assignee: Arbor Pharmaceuticals, LLCInventor: Hugh Greg Thomas
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Patent number: 11135296Abstract: Pharmaceutical compositions and dosage forms of (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate and/or methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate, containing low levels of certain impurities are disclosed.Type: GrantFiled: May 15, 2018Date of Patent: October 5, 2021Assignee: Arbor Pharmaceuticals, LLCInventors: Suresh Kumar Manthati, Sami Karaborni, Wei Chen
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Patent number: 11013703Abstract: The present invention provides oral solutions containing sotalol hydrochloride which advantageously avoid swallowing while providing with improved stability. The present invention also relates to methods of using the oral solutions for treatment of diseases and disorders, such as delay in reoccurrence of atrial fibrillation/atrial flutter and/or ventricular arrhythmias.Type: GrantFiled: January 9, 2019Date of Patent: May 25, 2021Assignee: Arbor Pharmaceuticals, LLCInventors: H. Greg Thomas, Jeffrey S. Kiel
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Patent number: 10945984Abstract: Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.Type: GrantFiled: August 22, 2013Date of Patent: March 16, 2021Assignee: Arbor Pharmaceuticals, LLCInventors: Kenneth C. Cundy, Sami Karaborni, Peter A. Virsik
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Patent number: 10940117Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.Type: GrantFiled: April 20, 2020Date of Patent: March 9, 2021Assignee: Arbor Pharmaceuticals, LLCInventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
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Patent number: 10716760Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.Type: GrantFiled: January 7, 2016Date of Patent: July 21, 2020Assignee: Arbor Pharmaceuticals, LLCInventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
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Publication number: 20200087272Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.Type: ApplicationFiled: April 29, 2019Publication date: March 19, 2020Applicant: Arbor Pharmaceuticals, LLCInventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
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Patent number: 10576070Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.Type: GrantFiled: May 9, 2019Date of Patent: March 3, 2020Assignee: Arbor Pharmaceuticals, LLCInventor: Hugh Greg Thomas
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Patent number: 10576055Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.Type: GrantFiled: November 30, 2018Date of Patent: March 3, 2020Assignee: Arbor Pharmaceuticals, LLCInventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
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Patent number: 10385014Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.Type: GrantFiled: March 7, 2018Date of Patent: August 20, 2019Assignee: ARBOR PHARMACEUTICALS, LLCInventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
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Patent number: 10342787Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.Type: GrantFiled: April 16, 2018Date of Patent: July 9, 2019Assignee: ARBOR PHARMACEUTICALS, LLCInventor: Hugh Greg Thomas
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Patent number: 10179118Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.Type: GrantFiled: March 24, 2014Date of Patent: January 15, 2019Assignee: ARBOR PHARMACEUTICALS, LLCInventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati