Patents Assigned to ARBOR PHARMACEUTICALS, LLC
  • Patent number: 11938111
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: March 26, 2024
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Patent number: 11850222
    Abstract: The present invention provides oral solutions containing sotalol hydrochloride which advantageously avoid swallowing while providing with improved stability. The present invention also relates to methods of using the oral solutions for treatment of diseases and disorders, such as delay in reoccurrence of atrial fibrillation/atrial flutter and/or ventricular arrhythmias.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: December 26, 2023
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: H. Greg Thomas, Jeffrey S. Kiel
  • Patent number: 11413277
    Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: August 16, 2022
    Assignee: Arbor Pharmaceuticals, LLC
    Inventor: Hugh Greg Thomas
  • Patent number: 11229621
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: January 22, 2020
    Date of Patent: January 25, 2022
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Patent number: 11229207
    Abstract: An avermectin-based topical formulation is disclosed which is useful for prevention and treatment of head lice (Pediculus humanus capitis). This topical formulation may be formulated as a shampoo-condition which comprises an effective amount of avermectin, solubilizers, suspending agents, preservatives, nonionic surfactants, humectants, a silicone compound, and water. Also disclosed are methods of using the topical formulations disclosed within this specification to treat either a susceptible or treatment-resistant strain of lice, as well as uses in the manufacture of a medicament for treating or preventing a lice infestation from a susceptible or treatment-resistant strain in a human patient.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: January 25, 2022
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Nicholas Spring, Garry T. Gwozdz
  • Patent number: 11207306
    Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: December 28, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventor: Hugh Greg Thomas
  • Patent number: 11135296
    Abstract: Pharmaceutical compositions and dosage forms of (N,N-diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate and/or methyl 4-morpholin-4-ylbutyl (2E)but-2-ene-1,4-dioate, containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: October 5, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Suresh Kumar Manthati, Sami Karaborni, Wei Chen
  • Patent number: 11013703
    Abstract: The present invention provides oral solutions containing sotalol hydrochloride which advantageously avoid swallowing while providing with improved stability. The present invention also relates to methods of using the oral solutions for treatment of diseases and disorders, such as delay in reoccurrence of atrial fibrillation/atrial flutter and/or ventricular arrhythmias.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: May 25, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: H. Greg Thomas, Jeffrey S. Kiel
  • Patent number: 10945984
    Abstract: Methods of reducing undesirable side effects during therapeutic treatment using monomethyl fumarate and prodrugs of monomethyl fumarate are disclosed.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: March 16, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Kenneth C. Cundy, Sami Karaborni, Peter A. Virsik
  • Patent number: 10940117
    Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: March 9, 2021
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
  • Patent number: 10716760
    Abstract: Improved oral dosage forms of methyl hydrogen fumarate and prodrugs thereof are disclosed. Methods of treating diseases such as multiple sclerosis and psoriasis using such dosage forms are also disclose.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: July 21, 2020
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Sami Karaborni, Sarina Grace Harris Ma, Chen Mao, Ching Wah Chong, Peter Robert Prinz Freed, Mesut Ciper, Stefanie Krenzlin, David J. Wustrow, Peter A. Virsik
  • Publication number: 20200087272
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: April 29, 2019
    Publication date: March 19, 2020
    Applicant: Arbor Pharmaceuticals, LLC
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai, Suresh K. Manthati
  • Patent number: 10576070
    Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: March 3, 2020
    Assignee: Arbor Pharmaceuticals, LLC
    Inventor: Hugh Greg Thomas
  • Patent number: 10576055
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: March 3, 2020
    Assignee: Arbor Pharmaceuticals, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati
  • Patent number: 10385014
    Abstract: The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The disclosures herein also relate to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: August 20, 2019
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Mark A. Gallop, Fenmei Yao, Maria J. Ludwikow, Thu Phan, Ge Peng
  • Patent number: 10342787
    Abstract: Non-aqueous liquid compositions comprising nimodipine having improved stability over aqueous compositions comprising nimodipine are provided herein. Methods of improving neurological outcome by reducing the incidence and severity of ischemic deficits in patients with subarachnoid hemorrhage from ruptured intracranial berry aneurysms with the non-aqueous liquid compositions of the present invention are also detailed herein.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: July 9, 2019
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventor: Hugh Greg Thomas
  • Patent number: 10179118
    Abstract: Pharmaceutical compositions and dosage forms of dimethyl fumarate containing low levels of certain impurities are disclosed.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: January 15, 2019
    Assignee: ARBOR PHARMACEUTICALS, LLC
    Inventors: Sami Karaborni, Wei Chen, Suresh Kumar Manthati