Abstract: The present invention relates to methods for selecting a candidate therapeutic agent for controlling mineralization of an extracellular matrix in a tissue of a subject. The invention further relates to a cell culture mineralization model comprising a culture of an extracellular matrix producing cell under conditions that support extracellular matrix formation and matrix maturation, a test compound, and means and methods for determining in expression levels of genes encoding matrix proteins.
Type:
Grant
Filed:
November 16, 2007
Date of Patent:
March 24, 2015
Assignee:
Arcarios B.V.
Inventors:
Johannes Petrus Thomas Maria Van Leeuwen, Hermanus Johannes Marco Eijken
Abstract: This invention relates to novel ?-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and/or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.
Type:
Grant
Filed:
September 22, 2009
Date of Patent:
June 18, 2013
Assignee:
Arcarios B.V.
Inventors:
Dirk Elewaut, August Lodewijk Verbruggen
Abstract: This invention relates to novel ?-cyclodextrin polysulfate compounds comprising from one to three 2-carboxyethyl substituents, and at least two sulfates groups per glucopyranose unit, which are useful as active ingredients for the treatment and/or prophylaxis of degenerative joint diseases, osteoarthritis, articular rheumatism, arthrosis or degenerative arthritis, or for the treatment of heparin-induced thrombocytopenia, or for cartilage repair or connective tissue repair.
Type:
Application
Filed:
September 22, 2009
Publication date:
July 14, 2011
Applicant:
ARCARIOS B.V.
Inventors:
Dirk Elewaut, August Lodewijk Verbruggen
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