Patents Assigned to ARCELLX, INC
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Patent number: 11827716Abstract: Provided herein are D domain containing polypeptides that specifically bind targets of interest, as are nucleic acids encoding the D domain containing polypeptides, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. Also provided herein are methods of making and using the D domain containing polypeptides, nucleic acids, vectors and host cells, for example, but not limited to, in diagnostic and therapeutic applications. Also provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and Adapters and their use in methods of directing immune responses to target cells. In some embodiments, the methods include the use of a CAR expressing cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or direct CAR expressing cell-mediated immune response in vitro and in vivo.Type: GrantFiled: November 14, 2022Date of Patent: November 28, 2023Assignee: ARCELLX, INC.Inventors: David Lafleur, Jeffrey S. Swers, Justin Edwards
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Patent number: 11730763Abstract: Provided herein are multi-functional chimeric antigen receptor (CAR)-based compositions and their use in directing immune responses to target cells. The compositions have uses that include treating hyperproliferative disorders such as cancer. The provided methods generally include the use of a CAR cell in combination with an Adapter. The Adapter confers the ability to modulate, alter, and/or redirect CAR cell-mediated immune response in vitro and in vivo. In some embodiments, the CAR cell comprises a genetic modification to reduce or eliminate the expression of a targeted antigenic determinant.Type: GrantFiled: November 14, 2018Date of Patent: August 22, 2023Assignee: Arcellx, Inc.Inventors: David M. Hilbert, Jeffrey S. Swers, David William Lafleur
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Patent number: 11464803Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.Type: GrantFiled: September 10, 2021Date of Patent: October 11, 2022Assignee: ARCELLX, INC.Inventors: David M. Hilbert, Jeffrey S. Swers
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Patent number: 11377482Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.Type: GrantFiled: November 14, 2018Date of Patent: July 5, 2022Assignee: ARCELLX, INC.Inventors: David M. Hilbert, Jeffrey S. Swers
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Patent number: 11318165Abstract: D domain (DD) containing polypeptides (DDpp) that specifically bind targets of interest (e.g., BCMA, CD123, CS1, HER2, AFP, and AFP p26) are provided, as are nucleic acids encoding the DDpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. DDpp such as DDpp fusion proteins, are also provided as are methods of making and using the DDpp. Such uses include, but are not limited to diagnostic and therapeutic applications.Type: GrantFiled: September 10, 2021Date of Patent: May 3, 2022Assignee: ARCELLX, INC.Inventors: David M. Hilbert, Jeffrey S. Swers
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Patent number: 11008397Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: GrantFiled: March 13, 2020Date of Patent: May 18, 2021Assignees: Subdomain, LLC, Arcellx, Inc.Inventors: David William Lafleur, David M. Hilbert
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Publication number: 20210002381Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: ApplicationFiled: March 20, 2020Publication date: January 7, 2021Applicants: SUBDOMAIN, LLC, ARCELLX, INC.Inventors: David William LAFLEUR, David M. HILBERT
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Patent number: 10662248Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: GrantFiled: April 4, 2016Date of Patent: May 26, 2020Assignees: Subdomain LLC, Arcellx, Inc.Inventors: David William Lafleur, David M. Hilbert
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Patent number: 10647775Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: GrantFiled: April 4, 2016Date of Patent: May 12, 2020Assignees: Subdomain LLC, Arcellx, Inc.Inventors: David William Lafleur, David M. Hilbert
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Publication number: 20180251521Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: ApplicationFiled: April 4, 2016Publication date: September 6, 2018Applicants: SUBDOMAIN, LLC, ARCELLX, INCInventors: David William LAFLEUR, David M. HILBERT
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Publication number: 20180251563Abstract: Provided herein are de novo binding domain containing polypeptides (DBDpp) that specifically bind a target of interest. Nucleic acids encoding the DBDpp, and vectors and host cells containing the nucleic acids are also provided. Libraries of DBDpp, methods of producing and screening such libraries and the DBDpp identified from such libraries and screens are also encompassed. Methods of making and using the DBDpp are additionally provided. Such uses include, without limitation, affinity purification, and diagnostic and therapeutic applications.Type: ApplicationFiled: April 4, 2016Publication date: September 6, 2018Applicants: SUBDOMAIN, LLC, ARCELLX, INC.Inventors: David William LAFLEUR, David M. HILBERT