Patents Assigned to ARCH BIOPHYSICS, INC.
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Patent number: 9422450Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide, optionally having a polyethylene glycol moiety covalently attached to the peptide, is bound to a substrate. The disclosed methods and composition are useful for reducing the frictional coefficient, inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: GrantFiled: April 13, 2012Date of Patent: August 23, 2016Assignee: ARCH BIOPHYSICS, INC.Inventors: Randall Thomas Irvin, Elisabeth Melika Davis, Dongyang Li, Daniel Abraham Muruve
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Patent number: 9096775Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: GrantFiled: April 14, 2011Date of Patent: August 4, 2015Assignee: Arch Biophysics, Inc.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li, Daniel Abraham Muruve
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Patent number: 8961984Abstract: The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals.Type: GrantFiled: October 7, 2010Date of Patent: February 24, 2015Assignee: Arch Biophysics, Inc.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li
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Publication number: 20140220368Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide, optionally having a polyethylene glycol moiety covalently attached to the peptide, is bound to a substrate. The disclosed methods and composition are useful for reducing the frictional coefficient, inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: ApplicationFiled: April 13, 2012Publication date: August 7, 2014Applicant: ARCH BIOPHYSICS, INC.Inventors: Randall Thomas Irvin, Elisabeth Melika Davis, Gongyang Li, Daniel Abraham Muruve
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Publication number: 20110293684Abstract: The present invention relates to a methods and composition in which a D-form or retro-inverso Pseudomonas pilin peptide is bound to a substrate. The disclosed methods and composition are useful for inhibiting biofilm formation by non-Pseudomonas bacteria, for reducing the inflammatory response to a material, for reducing corrosion of metals, and in biosensor applications.Type: ApplicationFiled: April 14, 2011Publication date: December 1, 2011Applicant: ARCH BIOPHYSICS, INC.Inventors: Randall T. Irvin, Elisabeth M. Davis, DongYang Li, Daniel Abraham Muruve
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Publication number: 20110087321Abstract: The present invention relates to a method for covalently attaching a compound to a stainless steel, tin, iron, or titanium substrate, by contacting exposed surface(s) of the substrate with a synthetic pilin peptide containing a disulfide loop derived from the C-terminal receptor binding protein of Type IV P. aeruginosa (T4P) pilin, to bind the pilin peptide to the exposed surface(s), and covalently attaching the compound to the pilin peptide. Also disclosed are a substrate formed by the method and a biosensor device that uses the uses. Also disclosed are methods for improving the corrosion resistance, adhesive force, hardness and electron work function of certain metals.Type: ApplicationFiled: October 7, 2010Publication date: April 14, 2011Applicant: ARCH BIOPHYSICS, INC.Inventors: RANDALL T. IRVIN, ELISABETH M. DAVIS, DONGYANG LI