Patents Assigned to Archemix Corporation
  • Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
    Patent number: 8039443
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Grant
    Filed: November 2, 2004
    Date of Patent: October 18, 2011
    Assignee: Archemix Corporation
    Inventors: Dilara Grate, John L. Diener, Charles Wilson, Thomas Greene McCauley
  • Aptamers that bind thrombin with high affinity
    Patent number: 7998939
    Abstract: The invention provides aptamers capable of binding to thrombin useful as therapeutics for and diagnostics of coagulation related disorders and/or other diseases or disorders in which thrombin has been implicated. The invention further provides materials and methods for the administration of aptamers capable of binding to thrombin.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: August 16, 2011
    Assignee: Archemix Corporation
    Inventors: John L. Diener, Jess Wagner-Whyte, David Fontana