Patents Assigned to Archemix LLC
  • APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
    Publication number: 20210332361
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: March 12, 2021
    Publication date: October 28, 2021
    Applicant: ARCHEMIX LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 10947544
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: March 16, 2021
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
    Publication number: 20190185858
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: February 28, 2019
    Publication date: June 20, 2019
    Applicant: ARCHEMIX LLC
    Inventors: CLAUDE BENEDICT, DAVID EPSTEIN, CHARLES WILSON, DILARA MCCAULEY, JEFFREY KURZ, MARKUS KURZ, THOMAS GREENE MCCAULEY, JAMES ROTTMAN
  • Aptamers comprising CPG motifs
    Patent number: 10100316
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: October 16, 2018
    Assignee: Archemix LLC
    Inventors: David Epstein, Dilara Grate, Martin Stanton, John L. Diener, Charles Wilson, Thomas Greene McCauley, Errol Desouza
  • APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
    Publication number: 20180030446
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: March 2, 2017
    Publication date: February 1, 2018
    Applicant: ARCHEMIX LLC
    Inventors: Claude BENEDICT, David EPSTEIN, Charles WILSON, Dilara MCCAULEY, Jeffrey KURZ, Markus KURZ, Thomas Greene MCCAULEY, James ROTTMAN
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 9617546
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: April 11, 2017
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Methods for identifying aptamer regulators
    Patent number: 9303262
    Abstract: Methods are provided for identifying aptamer regulators. Aptamer regulators are aptamers that bind to a target wherein binding of the aptamer regulator to the target increases the binding affinity of the target for a target partner relative to the affinity of the target for the target partner when the target is not bound by the aptamer regulator such that binding of the aptamer regulator to the target is a prerequisite for target-target partner complex formation.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: April 5, 2016
    Assignee: ARCHEMIX LLC
    Inventors: Charles Wilson, David Epstein, John L. Diener
  • Stabilized Aptamers to Platelet Derived Growth Factor and Their Use as Oncology Therapeutics
    Publication number: 20160053266
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: September 9, 2015
    Publication date: February 25, 2016
    Applicant: ARCHEMIX LLC
    Inventors: Dilara McCauley, John L. Diener, Charles Wilson, Thomas Greene McCauley
  • STABILIZED APTAMERS TO PLATELET DERIVED GROWTH FACTOR AND THEIR USE AS ONCOLOGY THERAPEUTICS
    Publication number: 20150140120
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used one or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptarmers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: October 3, 2014
    Publication date: May 21, 2015
    Applicant: ARCHEMIX LLC
    Inventors: Dilara McCauley, John L. Diener, Charles Wilson, Thomas Greene McCauley
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 8946184
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: February 3, 2015
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
    Patent number: 8853376
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: October 7, 2014
    Assignee: Archemix LLC
    Inventors: Dilara McCauley, John L. Diener, Charles Wilson, Thomas Greene McCauley
  • APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
    Publication number: 20130237589
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: March 4, 2013
    Publication date: September 12, 2013
    Applicant: ARCHEMIX LLC
    Inventors: Claude BENEDICT, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 8436164
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: May 7, 2013
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman
  • APTAMER THERAPEUTICS USEFUL IN THE TREATMENT OF COMPLEMENT-RELATED DISORDERS
    Publication number: 20120322860
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: June 18, 2012
    Publication date: December 20, 2012
    Applicant: ARCHEMIX LLC
    Inventors: CLAUDE BENEDICT, DAVID EPSTEIN, CHARLES WILSON, DILARA MCCAULEY, JEFFREY KURZ, MARKUS KURZ, THOMAS GREENE MCCAULEY, JAMES ROTTMAN
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 8236773
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: August 7, 2012
    Assignee: Archemix LLC
    Inventors: Claude Benedict, David Epstein, Charles Wilson, Dilara McCauley, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman