Patents Assigned to Archimica, Inc.
  • Process for the synthesis of amphetamine derivatives
    Patent number: 8487134
    Abstract: The invention relates to processes for preparing acylated amphetamine, methamphetamine and dexamphetamine derivatives by reacting the parent amine with the to be-coupled acid or a salt of the to-be coupled acid which acid is optionally protected, in the presence of an alkylphosphonic acid anhydride as coupling agent and, if the acid was protected then cleaving the protecting group(s), in a one-pot reaction or in two or more separate steps.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: July 16, 2013
    Assignee: Archimica, Inc.
    Inventors: Andreas Meudt, Richard Wisdom, Jason Helmke, Quofang Qiu, Paul Meek
  • Process of enantiomeric resolution of D,L-(±)-threo-methylphenidate
    Patent number: 7897777
    Abstract: A process for preparing the d-threo isomer of methylphenidate hydrochloride which includes (i) resolving a racemic mixture of racemic threo-methylphenidate hydrochloride with a less than stoichiometric amount of tertiary amine base to obtain a methylphenidate-chiral acid salt, (ii) basifying the methylphenidate-chiral acid salt to obtain methylphenidate free base, and (iii) converting the methylphenidate free base into d-threo-methylphenidate hydrochloride.
    Type: Grant
    Filed: January 5, 2007
    Date of Patent: March 1, 2011
    Assignee: Archimica, Inc.
    Inventors: Alexei Kalinin, Guofang Qiu, Thomas J. Marren, James E. Aldred, Jr., Yu Ji