Abstract: The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
Type:
Application
Filed:
March 16, 2017
Publication date:
June 29, 2017
Applicants:
MERCK SHARP & DOHME CORP., IONIS PHARMACEUTICALS, INC.
Inventors:
Balkrishen Bhat, Anne B. Eldrup, Thazha P. Prakash, Phillip Dan Cook, David B. Olsen, Steven S. Carroll, Malcolm MacCoss
Abstract: A method of microfiltration of inhaled air for nasal application and product for reducing the risk of inhalation of fine and ultra-fine (i.e., microscopic and submicroscopic) sized atmospheric pollutants by applying a formulation topically to the skin above the upper-lip and in close proximity of the nasal passages. The products of this formulation, when applied, create an electrostatic field for reducing the inhalation of fine and ultra-fine airborne pollutants.
Type:
Application
Filed:
March 14, 2017
Publication date:
June 29, 2017
Applicant:
TRUTEK Corp.
Inventors:
Ashok Wahi, John Lawrence Dequina, Kanika Wahi, Bernard Foss
Abstract: A curtain airbag for a vehicle may include a curtain airbag cushion divided into an upper cushion and a lower cushion, a folding portion at the upper cushion, and a door panel tether having a first end fixed to the folding portion and a second end fixed to a car body, in which when the curtain airbag inflates, a door side of the upper cushion may be pressed by the tension of the door panel tether and the upper cushion turns inward.
Type:
Application
Filed:
July 19, 2016
Publication date:
June 29, 2017
Applicants:
Hyundai Motor Company, Kia Motors Corp.
Abstract: A half-rate clock data recovery circuit includes: a voltage-controlled oscillator (VCO) for generating a data sampling clock and an edge sampling clock according to a control voltage; an adjusting circuit for dynamically controlling the VCO to adjust the phase difference between the data sampling clock and the edge sampling clock to be different from 90 degrees in multiple test periods; and a control circuit for instructing the adjusting circuit to respectively utilize different control value combinations to control the VCO in the multiple test periods, and for recording multiple recovered-signal quality indicators respectively corresponding to the multiple test periods. Afterwards, the control circuit instructs the adjusting circuit to utilize a control value combination corresponding to the best quality indicator among the multiple recovered-signal quality indicators to control the VCO.
Abstract: Phosphate-based linkers with tunable stability for intracellular delivery of drug conjugates are described. The phosphate-based linkers comprise a monophosphate, diphosphate, triphosphate, or tetraphosphate group (phosphate group) and a linker arm comprising a tuning element and optionally a spacer. A payload is covalently linked to the phosphate group at the distal end of the linker arm and the functional group at the proximal end of the linker arm is covalently linked to a cell-specific targeting ligand such as an antibody. These phosphate-based linkers have a differentiated and tunable stability in blood vs. an intracellular environment (e.g. lysosomal compartment).
Type:
Application
Filed:
March 30, 2015
Publication date:
June 29, 2017
Applicants:
Merck Sharp & Dohme Corp., Ambrx, Inc.
Inventors:
Robert M. Garbaccio, Jeffrey Kern, Philip E. Brandish, Sanjiv Shah, Linda Liang, Ying Sun, Jianing Wang, Nick Knudsen, Andrew Beck, Anthony Manibusan, Dennis Gately
Abstract: A storage container includes a bottom panel that has a parallel front edge and rear edge, and a parallel first and second side edge. A front panel is connected to the bottom panel along the front edge and is further connected with a front locking section. A first side panel is connected to the first side edge of the bottom panel and is further connected to a first side locking section. A second side panel is connected to the second side edge of the bottom panel and is further connected to a second side locking section. A rear panel is connected to the rear edge of the bottom panel and is further connected to a rear locking section. The rear panel has four deltoidal sections. The container is configured for rapid assembly.
Abstract: Embodiments of this disclosure provide an advertisement-downloading method, and an electronic device, wherein the method includes: in response to an operation, of sending an advertisement request that includes a link address of a third-party advertisement, of a client, searching whether the third-party advertisement downloaded from the link address of the third-party advertisement is pre-stored in a local CDN file address; and when the third-party advertisement downloaded from the link address of the third-party advertisement is pre-stored in the local CDN file address, redirect the advertisement request to the local CDN file address in which the third-party advertisement is stored, such that the client performs advertisement downloading.
Type:
Application
Filed:
August 22, 2016
Publication date:
June 29, 2017
Applicants:
LE HOLDINGS (BEIJING) CO., LTD., LE SHI INTERNET INFORMATION & TECHNOLOGY CORP., BEIJING
Abstract: The present invention generally relates to a travel bag or a packaging container. Specifically, embodiments of the present invention are directed toward a modular travel, garment bag or similar container system that can be customized based on the needs of the user. Furthermore, the various modules or segments of the bag may have different shapes and sizes so as to be adapted to carry items, with such modules or segments being combinable in varying arrangements to provide a flexibly configured bag that is suitable for a variety of uses. The present invention also relates to a packaging system for suits, blazers and jackets from garment, fashion and retail brands.
Abstract: A non-volatile memory device includes a plurality of memory cells. Each memory cell includes a vertical channel, a control gate, a floating gate, and an erase gate disposed on a substrate. The vertical channel extends upwards in a vertical direction. The control gate, the floating gate, and the erase gate surround the vertical channel respectively, and a part of the floating gate is surrounded by the control gate. The erase gate is disposed between the substrate and the floating gate in the vertical direction, and the floating gate include a tip extending toward the erase gate. The vertical channel and electrodes surrounding the vertical channel, such as the control gate, the floating gate, and the erase gate, are used to reduce the area of the memory cell on the substrate of the non-volatile memory device in the present invention. The density of the memory cells may be enhanced accordingly.
Abstract: A light-transmissible keycap and the manufacturing method thereof are provided. The light-transmissible keycap has multiple light-transmissible symbol areas, and each light-transmissible symbol area has at least one character assigned with a color. Each light-transmissible symbol area is covered with only one light-transmissible color layer. Thus, when an external light is emitted from a light source beneath the keycap, the external light will only pass through one light-transmissible color layer covering that light-transmissible symbol area, and not pass through the light-transmissible color layer covering the other light-transmissible symbol area. Therefore, a bleeding problem due to multiple light-transmissible color layers overlapped and covering the same light-transmissible symbol area is avoided.
Abstract: A system for operating a robotic arm comprises a carriage and a robotic arm. The carriage is mounted on a track adjacent to a rotary milking platform having a substantially circular perimeter and a stall for a dairy livestock. The carriage moves along a substantially straight portion of the track tangent to and outside the perimeter of the rotary milking platform at a rate based at least in part upon a speed of rotation of the rotary milking platform. The carriage moves in a direction corresponding to the direction of rotation of the rotary milking platform and such movement of the carriage is independent of any physical coupling between the carriage and the rotary milking platform. The robotic arm extends between the legs of the dairy livestock.
Type:
Grant
Filed:
September 7, 2016
Date of Patent:
June 27, 2017
Assignee:
Technologies Holdings Corp.
Inventors:
Henk Hofman, Peter Willem van der Sluis, Ype Groensma
Abstract: The disclosure provides methods of preventing or treating Barth Syndrome in a mammalian subject, reducing risk factors associated with Barth Syndrome, and/or reducing the likelihood or severity of Barth Syndrome. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to increase expression of TAZ1 in subjects in need thereof.
Abstract: A delivery vehicle for bioactive agents and live probiotic microbes to aquatic animals protects the bioactive compounds and microbes from digestion and destruction in the animal stomach. It provides for controlled release of bioactive agents and live probiotic microbes to aquatic animals in the form of dry or wet beadlets with essential nutrients and attractants bound with soluble starch and cross-linked alginate. The bioactive agents and live probiotic microbes can be bound with emulsified high-amylose starch and embedded in the beadlets in the form of microparticles.
Abstract: A troche comprising at least 5 mg hyaluronan, wherein the troche is adherent, and wherein hyaluronan is released from the troche, is used to treat mucositis, including stomatitis, vestibulitis, aphthous ulcerations, lichen planus and Behcet's syndrome. A method for treating or preventing mucositis in a patient is provided, comprising applying to a mucosal surface or a tooth or orthodontic brace of a patient in need thereof an adhering troche comprising at least 5 mg hyaluronan.
Abstract: An ESD protection device and a method of forming the same, the ESD device includes a substrate, a first doped well, a second doped well, a source and drain regions and a guard ring. The first doped well with a first conductive type is disposed in the substrate. The source and drain regions with the second conductive type are disposed in the first doped well. The guard ring with the first conductive type is also disposed in the first doped well and has a first portion extending along a first direction and a second portion extending along a second direction different from the first direction. The second doped well with the second conductive type is also disposed in the first doped well between the drain region and the second portion of the guard ring to in contact with the drain region in the first direction.
Type:
Grant
Filed:
April 11, 2016
Date of Patent:
June 27, 2017
Assignee:
UNITED MICROELECTRONICS CORP.
Inventors:
Mei-Ling Chao, Tien-Hao Tang, Kuan-Cheng Su
Abstract: A method of reading data for a display drive IC of a panel is provided. The method includes receiving a write format and at least one image packet, generating a synchronization signal according to the write format, and reading data of the at least one image packet according to the synchronization signal such that the panel uses a video mode to display the data of the at least one image packet.