Abstract: 4,6-dichloro-2-methyl-5-(1-acyl-2-imidazolin-2-yl)-aminopyrimidine is reacted with methanol in the presence of a non-ionic organic base, and moxonidine is obtained directly from the reaction mixture.
Type:
Grant
Filed:
February 5, 2014
Date of Patent:
May 26, 2015
Assignee:
AREVIPHARMA GmbH
Inventors:
Harald Hofmeier, Michael Limmert, Heike Heydemüller, Helge Hartenhauer