Abstract: A power unit for supplying electric energy to at least one electrode of an electronic apparatus for delivering Coherent Sine Burst Irreversible Electroporation energy, including at least one power module to generate an electric signal (S) to energize one or more respective electrodes, the power module comprising a selecting block configured to receive at least one square wave input signal and continuously change the electric energy level associated with said electric signal (S) based on the at least one square wave input signal in order to provide a combined signal at an output of the selecting block, wherein the combined signal comprises a square wave waveform; and a filtering and electrical isolation block configured to convert the combined signal into a sine wave signal and to filter the sine wave signal to generate the electric signal (S), wherein the conversion and filtering are electrically isolated from one another.

Abstract: There is disclosed a composition comprising one or more calcium salts, for use in a treatment or augmenting treatment of non-thermal ablation, the treatment comprising: administering an effective amount of said composition to the subject via a systemic route of administration; delivering non-thermal ablative energy to the target tissue. There is further disclosed ablation equipment for delivering non-thermal energy to treat target regions of tissue in organs, wherein a single power source is configured to generate electric sinusoidal voltage signals to energize each electrode of the equipment; and wherein the single power source is configured to supply at least first and second electrodes that are adjacent to each other on said ablation catheter, with sinusoidal electric voltage signals in phase or out of phase with each other to generate a unipolar electric field and/or a bipolar electric field for delivering the non-thermal energy to the tissue to be treated.

Abstract: Provided herein are systems, devices, and methods for delivering electroporation energy to treat target tissue. The system includes a generator for providing an electroporation waveform. The generator includes a signal generator for generating the electroporation waveform and a controller for providing signaling that causes the signal generator to generate the electroporation waveform. The system further includes a catheter including at least one catheter electrode. The signal generator provides the electroporation waveform to the at least one catheter electrode. The electroporation waveform includes a plurality of energy pulses, and each energy pulse is separated by an inter-pulse delay period.

Abstract: The present invention relates to an ablation assembly to treat target regions of a tissue in organs comprising: an ablation catheter comprising an elongate shaft having a longitudinal main direction (X-X), said elongate shaft comprising at least a shaft distal portion, said shaft distal portion comprising a shaft distal portion distal end; said ablation catheter comprising an inner lumen arranged within the elongate shaft; said ablation catheter comprising a shaft ablation assembly fixedly disposed at said shaft distal portion, the shaft ablation assembly being configured to deliver both thermal energy for ablating said tissue and non-thermal energy for treating said tissue; at least a shape setting mandrel disposed within the ablation catheter, the shape setting mandrel being insertable within the inner lumen and removable from the inner lumen, wherein the shape setting mandrel is free to move in respect of the inner lumen avoiding any constraint with said shaft distal portion during the shape setting

Abstract: A power unit for supplying electric energy to at least one electrode of an electronic apparatus for delivering Coherent Sine Burst Irreversible Electroporation energy, including at least one power module to generate an electric signal (S) to energize one or more respective electrodes, the power module comprising a selecting block configured to receive at least one square wave input signal and continuously change the electric energy level associated with said electric signal (S) based on the at least one square wave input signal in order to provide a combined signal at an output of the selecting block, wherein the combined signal comprises a square wave waveform; and a filtering and electrical isolation block configured to convert the combined signal into a sine wave signal and to filter the sine wave signal to generate the electric signal (S), wherein the conversion and filtering are electrically isolated from one another.

Abstract: Electronic apparatus (100) for delivering Coherent Sine Burst Irreversible Electroporation energy to a biological tissue (1) comprises at least one electrode (3) positionable on or near the biological tissue (1), a power generator (2) for supplying electric energy to the electrode (3), and to generate a respective electric signal (S) to energize the electrode (3). The electric signal (S) is formed by alternating over time a first electric signal (S1) with a second electric signal (S2), with each first electric signal (S1) being the same. The first electric signal (S1) is supplied to electrode (3) during a first time interval (T1) and the second electric signal (S2) is supplied to electrode (3) during a second time interval (T2), subsequent to the first time interval (T1). The first electric signal (S1) is a continuous bipolar signal which comprises two or more basic sine waves (SB) in the first time interval (T1).