Patents Assigned to Ariosa Diagnostics, In.
  • Multiplexed sequential ligation-based detection of genetic variants
    Patent number: 9624490
    Abstract: The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: April 18, 2017
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Jacob Zahn, Arnold Oliphant, Morassa Mohseni
  • Detection of target nucleic acids using hybridization
    Patent number: 9567639
    Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 14, 2017
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Jacob Zahn, Kara Juneau, Patrick Bogard, Stephanie Huang
  • Multiplexed sequential ligation-based detection of genetic variants
    Patent number: 9206417
    Abstract: The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: December 8, 2015
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Jacob Zahn, Arnold Oliphant, Morassa Mohseni
  • NON-INVASIVE FETAL SEX DETERMINATION
    Publication number: 20140256572
    Abstract: The present invention provides methods for non-invasive determination of sex in a fetus or of Y chromosomal frequency abnormalities—indicative of aneuploidy or sex mosaicisms in a fetus—by detecting and determining the relative contribution genetic sequences from the Y chromosome in view of the percent fetal contribution in a maternal mixed sample.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 11, 2014
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventors: Craig Struble, Arnold Oliphant, Eric Wang
  • DETECTION OF GENETIC ABNORMALITIES USING LIGATION-BASED DETECTION AND DIGITAL PCR
    Publication number: 20140242582
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides combined with digital PCR detection.
    Type: Application
    Filed: February 18, 2014
    Publication date: August 28, 2014
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Jacob Zahn
  • DETERMINATION OF COPY NUMBER VARIATIONS USING BINOMIAL PROBABILITY CALCULATIONS
    Publication number: 20140188401
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Application
    Filed: February 10, 2014
    Publication date: July 3, 2014
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • DETERMINATION OF COPY NUMBER VARIATIONS USING BINOMIAL PROBABILITY CALCULATIONS
    Publication number: 20140180602
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 26, 2014
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • Enhanced risk probabilities using biomolecule estimations
    Patent number: 8756020
    Abstract: The present invention provides processes for determining more accurate risk probabilities for medical conditions. The risk probabilities of the presence or absence of a medical condition are calculated using frequency data from selected biomolecules and biomolecule source contribution of at least one source in a mixed sample.
    Type: Grant
    Filed: October 15, 2011
    Date of Patent: June 17, 2014
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, Eric Wang, Andrew Sparks, Arnold Oliphant
  • Determination of copy number variations using binomial probability calculations
    Patent number: 8712697
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: April 29, 2014
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • MATHEMATICAL NORMALIZATION OF SEQUENCE DATA SETS
    Publication number: 20140095136
    Abstract: The invention provides processes of the present invention provide normalization procedures for sequences within multiplexed data sets using the sequence information from multiplexed sequencing data set itself rather than the utilization of any external references.
    Type: Application
    Filed: December 17, 2012
    Publication date: April 3, 2014
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: ARIOSA DIAGNOSTICS, INC.
  • MULTIPLEXED SEQUENTIAL LIGATION-BASED DETECTION OF GENETIC VARIANTS
    Publication number: 20140024538
    Abstract: The present invention provides multiplexed sequential ligation-based analysis of genetic variants in a mixed sample, including copy number variations and single nucleotide polymorphisms. The invention employs the techniques of sequential ligation and amplification.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 23, 2014
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: Jacob Zahn, Arnold Oliphant, Morassa Mohseni
  • NONINVASIVE DETECTION OF ROBERTSONIAN TRANSLOCATIONS
    Publication number: 20130310262
    Abstract: The present invention provides methods for detection of Robertsonian translocations.
    Type: Application
    Filed: May 21, 2013
    Publication date: November 21, 2013
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: Jacob Zahn, Arnold Oliphant, Eric Wang, Craig Struble
  • PROCESSES FOR CALCULATING PHASED FETAL GENOMIC SEQUENCES
    Publication number: 20130311107
    Abstract: The present invention provides processes for calculating phased genomic sequences of the fetal genome using fetal DNA obtained from a maternal sample. The processes and systems of the present invention utilize novel technological and computational approaches to detect fetal genomic sequences and determine the phased heritable genomic sequences. The invention could be used, e.g., to identify in utero deleterious mutations carried by the parents and inherited by a fetus within a particular heritable genomic region.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 21, 2013
    Applicant: Ariosa Diagnostics, Inc.
    Inventors: John Stuelpnagel, Craig Struble, Eric Wang
  • LIGATION-BASED DETECTION OF GENETIC VARIANTS
    Publication number: 20130261003
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation—e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization.
    Type: Application
    Filed: March 15, 2013
    Publication date: October 3, 2013
    Applicant: Ariosa Diagnostics, In.
    Inventors: Arnold Oliphant, Andrew Sparks, John Stuelpnagel, Ken Song
  • ASSAY SYSTEMS FOR GENETIC ANALYSIS
    Publication number: 20130210640
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Application
    Filed: March 8, 2013
    Publication date: August 15, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: ARIOSA DIAGNOSTICS, INC.
  • NONINVASIVE DETECTION OF FETAL ANEUPLOIDY IN EGG DONOR PREGNANCIES
    Publication number: 20130178371
    Abstract: The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.
    Type: Application
    Filed: December 19, 2012
    Publication date: July 11, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: ARIOSA DIAGNOSTICS, INC.
  • LIGATION-BASED DETECTION OF GENETIC VARIANTS
    Publication number: 20130172213
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 4, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: Ariosa Diagnostics, Inc.
  • LIGATION-BASED DETECTION OF GENETIC VARIANTS
    Publication number: 20130172211
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 4, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: Ariosa Diagnostics, Inc.
  • LIGATION-BASED DETECTION OF GENETIC VARIANTS
    Publication number: 20130172212
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation, i.e. the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides.
    Type: Application
    Filed: March 8, 2013
    Publication date: July 4, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: Ariosa Diagnostics, Inc.
  • DETECTION OF GENETIC ABNORMALITIES
    Publication number: 20130143213
    Abstract: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.
    Type: Application
    Filed: November 29, 2012
    Publication date: June 6, 2013
    Applicant: ARIOSA DIAGNOSTICS, INC.
    Inventor: Ariosa Diagnostics, Inc.