Patents Assigned to ARIOSA DIAGNOSTICS, INC.
  • Assay systems for genetic analysis
    Patent number: 11299772
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: April 12, 2022
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Craig Struble, Eric Wang, Arnold Oliphant
  • Determination of copy number variations using binomial probability calculations
    Patent number: 11289176
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 29, 2022
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • Statistical analysis for non-invasive sex chromosome aneuploidy determination
    Patent number: 11270781
    Abstract: The present invention provides methods for non-invasive determination of X and/or Y chromosomal abnormalities indicative of aneuploidy or sex mosaicisms in a maternal sample by detecting and determining the relative contribution of genetic sequences from the X chromosome and/or the Y chromosome in the maternal sample.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: March 8, 2022
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, Arnold Oliphant, Eric Wang
  • Detection of target nucleic acids using hybridization
    Patent number: 11203786
    Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: December 21, 2021
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Jacob Zahn, Kara Jeneau, Patrick Bogard, Stephanie Huang
  • Assay systems for genetic analysis
    Patent number: 11091807
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: August 17, 2021
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Arnold Oliphant, Jacob Zahn, Ken Song, John Stuelpnagel
  • Assay systems for determination of fetal copy number variation
    Patent number: 11031095
    Abstract: The present invention provides processes for determining accurate risk probabilities for chromosome dosage abnormalities. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: June 8, 2021
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: John Stuelpnagel, Ken Song, Arnold Oliphant, Craig Struble
  • Ligation-based detection of genetic variants
    Patent number: 10954566
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation—, e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: March 23, 2021
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, John Stuelpnagel, Ken Song
  • Assay systems for genetic analysis
    Patent number: 10907198
    Abstract: The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: February 2, 2021
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Arnold Oliphant, Jacob Zahn, Ken Song, John Stuelpnagel
  • Determination of copy number variations using binomial probability calculations
    Patent number: 10847250
    Abstract: This invention relates to a binomial calculation of copy number of data obtained from a mixed sample having a first source and a second source.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: November 24, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Craig Struble, John Stuelpnagel
  • Risk calculation for evaluation of fetal aneuploidy
    Patent number: 10718024
    Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 21, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
  • Risk calculation for evaluation of fetal aneuploidy
    Patent number: 10718019
    Abstract: The present invention provides processes for determining accurate risk probabilities for fetal aneuploidies. Specifically, the invention provides non-invasive evaluation of genomic variations through chromosome-selective sequencing and non-host fraction data analysis of maternal samples.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: July 21, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, Eric Wang, Craig Struble
  • Detection of target nucleic acids using hybridization
    Patent number: 10533223
    Abstract: The present invention provides detection systems and methods for detection of loci and genomic regions in a sample, including mixed samples, using hybridization to an array.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: January 14, 2020
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Jacob Zahn, Kara Juneau, Patrick Bogard, Stephanie Huang
  • Assay systems for determination of source contribution in a sample
    Patent number: 10308981
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: June 4, 2019
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Craig Struble, Eric Wang, Arnold Oliphant
  • Ligation-based detection of genetic variants
    Patent number: 10233496
    Abstract: The present invention provides assays systems and methods for detection of genetic variants in a sample, including copy number variation and single nucleotide polymorphisms. The invention preferably employs the technique of tandem ligation—, e.g., the ligation of two or more fixed sequence oligonucleotides and one or more bridging oligonucleotides complementary to a region between the fixed sequence oligonucleotides—combined with detection of levels of particular genomic regions using array hybridization.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: March 19, 2019
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Arnold Oliphant, Andrew Sparks, John Stuelpnagel, Ken Song
  • Detection of genetic abnormalities
    Patent number: 10167508
    Abstract: The present invention provides assay systems and related methods for determining genetic abnormalities in mixed samples comprising cell free DNA from both normal and putative genetically atypical cells. Exemplary mixed samples for analysis using the assay systems of the invention include samples comprising both maternal and fetal cell free DNA and samples that contain DNA from normal cells and circulating cancerous cells.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: January 1, 2019
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Ken Song, Arnold Oliphant, John Stuelpnagel, Andrew Sparks
  • Noninvasive detection of fetal aneuploidy in egg donor pregnancies
    Patent number: 10131947
    Abstract: The present invention provides assay systems and methods for determining the percent fetal contribution of cell-free DNA in a maternal sample from a pregnant female with an egg donor pregnancy. Further provided, are assay systems and methods for determining a statistical likelihood of the presence or absence of a fetal aneuploidy in a maternal sample using a determined percent fetal cell-free DNA in the sample.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: November 20, 2018
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Arnold Oliphant, Eric Wang, Craig Struble
  • Assay systems for genetic analysis
    Patent number: 10131937
    Abstract: The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source.
    Type: Grant
    Filed: November 10, 2011
    Date of Patent: November 20, 2018
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Andrew Sparks, Arnold Oliphant, Jacob Zahn, Ken Song, John Stuelpnagel
  • Assay systems for genetic analysis
    Patent number: 10131951
    Abstract: The present invention provides assay systems and methods for detection of copy number variation at one or more loci and polymorphism detection at one or more loci in a mixed sample from an individual.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: November 20, 2018
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Andrew Sparks, Arnold Oliphant, Jacob Zahn, Ken Song, John Stuelpnagel
  • Non-invasive fetal sex determination
    Patent number: 9994897
    Abstract: The present invention provides methods for non-invasive determination of sex in a fetus or of Y chromosomal frequency abnormalities—indicative of aneuploidy or sex mosaicisms in a fetus—by detecting and determining the relative contribution genetic sequences from the Y chromosome in view of the percent fetal contribution in a maternal mixed sample.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: June 12, 2018
    Assignee: ARIOSA DIAGNOSTICS, INC.
    Inventors: Craig Struble, Arnold Oliphant, Eric Wang
  • Assay systems for genetic analysis
    Patent number: 9890421
    Abstract: The present invention provides assays systems and methods for detection of chromosomal abnormalities and status of single loci associated with monogenic or polygenic traits in a sample containing nucleic acids from a maternal and a fetal source.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: February 13, 2018
    Assignee: Ariosa Diagnostics, Inc.
    Inventors: Andrew Sparks, Arnold Oliphant, Jacob Zahn, Ken Song, John Stuelpnagel