Patents Assigned to Arius Research, Inc.
  • Patent number: 7488475
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: February 10, 2009
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Helen P. Findlay
  • Patent number: 7456258
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 25, 2008
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Lisa M. Cechetto
  • Patent number: 7456259
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 25, 2008
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Lisa M. Cechetto
  • Patent number: 7452978
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 18, 2008
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Lisa M. Cechetto
  • Patent number: 7452979
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: July 31, 2006
    Date of Patent: November 18, 2008
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Lisa M. Cechetto
  • Patent number: 7009040
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: March 7, 2006
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Helen P. Findlay
  • Publication number: 20050255041
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: May 13, 2004
    Publication date: November 17, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Helen Findlay
  • Publication number: 20050191305
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 1, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Lisa Cechetto
  • Publication number: 20050191306
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: February 25, 2005
    Publication date: September 1, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Lisa Cechetto
  • Publication number: 20050063967
    Abstract: This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.
    Type: Application
    Filed: September 24, 2004
    Publication date: March 24, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Helen Findlay, Alison Ferry
  • Publication number: 20050053609
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: September 15, 2004
    Publication date: March 10, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Helen Findlay
  • Publication number: 20050002940
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: July 15, 2004
    Publication date: January 6, 2005
    Applicant: Arius Research, Inc.
    Inventors: David Young, Susan Hahn, Helen Findlay
  • Publication number: 20040253653
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 16, 2004
    Applicant: Arius Research, Inc.
    Inventors: David S.F. Young, Susan E. Hahn, Helen P. Findlay
  • Patent number: 6794494
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: September 21, 2004
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn
  • Publication number: 20040151665
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: January 20, 2004
    Publication date: August 5, 2004
    Applicant: Arius Research, Inc.
    Inventors: David S. F. Young, Susan E. Hahn, Helen P. Findlay
  • Publication number: 20040141979
    Abstract: The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 22, 2004
    Applicant: Arius Research, Inc.
    Inventors: David S.F. Young, Susan E. Hahn, Helen P. Findlay
  • Patent number: 6657048
    Abstract: The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: December 2, 2003
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Miyoko Takahashi
  • Patent number: 6180357
    Abstract: The present invention relates to a method for producing patient specific anti-cancer antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies customized for the individual patient that can be used for therapeutic and diagnostic purposes. The invention further relates to the process by which the antibodies are made and to their methods of use. The antibodies can be made specifically for one tumor derived from a particular patient and are selected on the basis of their cancer cell cytotoxicity and simultaneous lack of toxicity for non-cancerous cells. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat tumor metastases.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: January 30, 2001
    Assignee: Arius Research, Inc.
    Inventors: David S. F. Young, Miyoko Takahashi