Abstract: The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided.
Type:
Grant
Filed:
October 7, 2010
Date of Patent:
October 8, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona Acting for and on Behalf of Arizona State University
Abstract: The present invention relates generally to plasmonic structures, methods for making them, and devices including them. In one aspect, a plasmonic structure includes a plurality of metal particles disposed on a substrate; and one or more metal structures electrically coupled to and disposed on a surface of each of the plurality of metal particles. The metal structures have a structure that is different than the structure of the metal particles. The metal structures can be grown, for example, by electrodeposition on the metal particles. Growth of such metal structures can tune the response of the plasmonic structure.
Type:
Application
Filed:
November 11, 2011
Publication date:
August 29, 2013
Applicant:
Arizona Board of Regents, a body Corporate of the State of Arizona acting for and on behalf of Arzon
Abstract: Embodiments and examples of differential threshold voltage non-volatile memories and related methods are described herein. Other embodiments, examples thereof, and related methods are also disclosed herein.
Type:
Grant
Filed:
April 8, 2011
Date of Patent:
July 16, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Inventors:
Sameer M. Venugopal, David R. Allee, Lawrence T Clark, Nazanin Darbanian
Abstract: Some embodiments teach a method of preparing a flexible substrate assembly. The method can include: (a) providing a carrier substrate; (b) providing a cross-linking adhesive; (c) providing a plastic substrate; and (d) coupling the carrier substrate to the plastic substrate using the cross-linking adhesive. Other embodiments are disclosed in this application.
Type:
Grant
Filed:
May 27, 2011
Date of Patent:
July 9, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Inventors:
Jesmin Haq, Scott Ageno, Douglas E. Loy, Shawn O'Rourke, Robert Naujokaitis
Abstract: Embodiments and examples of differential threshold voltage non-volatile memories and related methods are described herein. In one example, a method for providing an integrated circuit can comprise providing a memory cell coupled to a first bitline and to a second bitline, and at least one of (a) providing a read assist mechanism configured to couple to the memory cell via the first and second bitlines, or (b) providing a memory reset mechanism configured to couple to the memory cell via the first and second bitlines. Providing the memory cell can comprise providing a first transistor comprising a first threshold voltage, providing a second transistor comprising a second threshold voltage, and cross-coupling the first and second transistors of the memory cell together. A difference between the first and second threshold voltages can correspond to a logic state of the memory cell. Other embodiments, examples, and related methods are also disclosed herein.
Type:
Grant
Filed:
April 8, 2011
Date of Patent:
June 11, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Inventors:
Sameer M. Venugopal, David R. Allee, Lawrence T. Clark
Abstract: Systems and methods of the present disclosure provide for three-dimensional stacks of microelectromechanical (MEMS) systems, such as sensors. The stacks may be encapsulated and sealed, and can be positioned within biological tissue, for example to monitor biological signals within the volume of the sensor, provide stimulating signals to a brain, and so forth.
Type:
Application
Filed:
December 11, 2012
Publication date:
May 30, 2013
Applicant:
Arizona Board of Regents, a body corporate for the State of Arizona acting for and on behalf of Ariz
Inventor:
Arizona Board of Regents, a body corporate for the State of Arizona acting for and on behalf of Arizona State
Abstract: Systems, methods, and media for on-line boosting of a classifier are provided, comprising: receiving a training sample; for each of a plurality of features, determining a feature value for the training sample and the feature, using the feature value to update a histogram, and determining a threshold for a classifier of the feature; for each of the plurality of features, classifying the training sample using the threshold for the classifier of the feature and calculating an error associated with the classifier; selecting a plurality of best classifiers from the classifiers; and, for each of the plurality of best classifiers, assigning a voting weight to the one of the plurality of best classifiers.
Type:
Application
Filed:
September 17, 2012
Publication date:
March 21, 2013
Applicant:
Arizona Board of Regents, a Body Corporate of the State of Arizona, acting for and on behalf of Ariz
Inventors:
Nima Tajbakhsh, Hong Wu, Wenzhe Xue, Jianming Liang
Abstract: In some embodiments, a method of etching an organosiloxane dielectric material can include: (a) providing the organosiloxane dielectric material; (b) providing a patterned mask over the organosiloxane dielectric material; and (c) reactive ion etching the organosiloxane dielectric material. Other embodiments are disclosed in this application.
Type:
Grant
Filed:
May 27, 2011
Date of Patent:
February 26, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Abstract: A flexible, transparent electrode structure and a method of fabrication thereof are provided comprising a transparent electrode which may maintain electrical connectivity across a surface of a flexible substrate so that the substrate may flex without affecting the integrity of an electrical contact. The transparent electrode includes conductive nanowires that are coupled to the substrate through a conducting oxide layer. The conducting oxide layer effectively provides a template onto which the nanowires are deposited and serves to anchor the nanowires to the substrate surface.
Type:
Grant
Filed:
January 18, 2008
Date of Patent:
January 29, 2013
Assignee:
Arizona Board of Regents, a body corporate of the state of Arizona acting for and on behalf of Arizona State University
Abstract: The present invention provides a debonding apparatus, a system comprising such apparatus, and methods for using such apparatus or system for the removal of flexible substrates (14) post-processing without damage to fabricated devices.
Type:
Grant
Filed:
March 25, 2009
Date of Patent:
January 8, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Arizona State University
Inventors:
Robert Blanchard, R. Steve Rednour, Douglas Loy
Abstract: Two-terminal multi junction photodetectors and focal plane arrays for multi-color detection or imaging acquisition can be formed by connecting photodiodes with different bandgaps or wavelengths, through tunnel diodes, in series with the same polarization. Under reverse bias in the dark, the total current going through such multi junction photodetectors is dictated by the smallest reverse saturation current of the photodiodes. When in operating mode, a set of light sources with different wavelengths corresponding to each individual photodiode can be used to optically bias all the photodiodes except the detecting photodiode Under illumination, all other photodiodes work in the photovoltaic mode and have much higher maximum possible reverse currents than the detecting photodiode. As a result, the total current of the multi junction photodetector is dictated by the detecting photodiode.
Type:
Grant
Filed:
January 21, 2011
Date of Patent:
January 8, 2013
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
Inventors:
Yong-Hang Zhang, Ding Ding, Elizabeth Steenbergen
Abstract: The present invention relates generally to the detection of high energy radiation. The present invention relates more particularly to the film bulk acoustic wave resonator-based devices, and their use in the detection of high energy radiation. One aspect of the invention is a method for detecting high energy radiation, the method comprising providing a film bulk acoustic wave resonator having a zinc oxide piezoelectric layer in substantial contact with a dielectric layer; exposing the film bulk acoustic wave resonator to the high energy radiation; determining the resonant frequency of the film bulk acoustic wave resonator; and determining the dose of high energy radiation using the resonant frequency of the film bulk acoustic wave resonator.
Type:
Application
Filed:
January 20, 2011
Publication date:
December 27, 2012
Applicant:
Arizona Board of Regents, A Body Corporate of the State of Arizona Acting for and on Behalf ASU
Inventors:
Hongyu Yu, Jonathon Keith Oiler, Hugh James Barnaby
Abstract: A solar cell assembly can be prepared having one or more laterally-arranged multiple bandgap (LAMB) solar cells and a dispersive concentrator positioned to provide light to a surface of each of the LAMB cells. As described herein, each LAMB cell comprises a plurality of laterally-arranged solar cells each having a different bandgap.
Type:
Application
Filed:
June 14, 2012
Publication date:
December 20, 2012
Applicant:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Ariz
Abstract: The present invention relates generally to the detection of alcohol. The present invention relates more particularly to the film bulk acoustic wave resonator-based devices, and their use in the sensing of ethanol and/or acetone. One aspect of the invention is a method for detecting ethanol, acetone or both in a gaseous sample including: providing a film bulk acoustic wave resonator having a zinc oxide piezoelectric layer; exposing the film bulk acoustic wave resonator to the gaseous sample; determining the resonant frequency of the film bulk acoustic wave resonator; and determining the concentration of ethanol, the concentration of acetone, or both in the gaseous sample using the resonant frequency of the film bulk acoustic wave resonator.
Type:
Application
Filed:
January 20, 2011
Publication date:
November 29, 2012
Applicant:
Arizona Board of Regents, a body Corporate of the States of Arizona acting for and on behalf of Ariz
Abstract: Embodiments of sensor systems and related methods of operating and manufacturing the same are described herein. The sensor systems can be used to detect atomic or subatomic particles or radiation. Other embodiments and related methods are also disclosed herein.
Type:
Grant
Filed:
April 27, 2012
Date of Patent:
November 27, 2012
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Abstract: Embodiments of amplifiers with depletion and enhancement mode thin film transistors are disclosed herein. Other examples, devices, and related methods are also disclosed herein.
Type:
Grant
Filed:
March 2, 2012
Date of Patent:
November 27, 2012
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on behalf of Arizona State University
Inventors:
Sameer M. Venugopal, Aritra Dey, David R. Allee
Abstract: The present invention provides for the treatment of Alzheimer's disease. More specifically, a recombinant bispecific antibody fragment that simultaneously blocks beta-secretase activity while also promoting alpha-secretase activity, comprising a first portion and a second portion, wherein the first portion blocks beta secretase activity and the second portion promotes alpha-secretase activity.
Type:
Application
Filed:
September 8, 2010
Publication date:
September 13, 2012
Applicant:
Arizona Board of Regents, a body corporate of the State of Arizona, Acting for and on Behalf of Ariz
Inventors:
Michael Sierks, Shanta Boddapati, Srinath Kasturirangan
Abstract: The present invention provides methods for generating a distribution of optimal answers to a nondeterministic polynomial optimization problem by providing a plurality of solutions comprising input polynucleotides, wherein each solution comprises identical input polynucleotides; and wherein the number of solutions comprising polynucleotides equals a number of data inputs in the problem to be answered, and wherein each input polynucleotide comprises an x segment and a y segment; providing a plurality of solutions comprising connection polynucleotides wherein each solution comprises identical connection polynucleotides; and wherein the number of solutions comprising connection polynucleotides equals a number of unique connections that can be made between the different data inputs, and wherein each polynucleotide in the set of connection polynucleotides is complementary to the x segment of one input polynucleotide and to the y segment of one different input polynucleotide; combining the solutions comprising the i
Type:
Grant
Filed:
July 28, 2008
Date of Patent:
February 28, 2012
Assignee:
Arizona Board of Regents, a body corporate of the State of Arizona acting for and on behalf of Arizona State University
Inventors:
Wayne Frasch, David Spetzler, Justin York, Fusheng Xiong