Abstract: This disclosure relates generally to sequential state elements (SSEs). More specifically, embodiments of flip-flops are disclosed, along with computerized methods and systems of designing the same. In one embodiment, the flip-flop includes a substrate and subcircuits that are formed on the substrate. The subcircuits provide subfunctions, wherein each of the subcircuits provides at least one of the subfunctions. More specifically, the subfunctions are provided in a sequential logical order by the subcircuits so that the flip-flop provides a flip-flop function. However, the subcircuits are interleaved out of the sequential logical order with respect to a corresponding subfunction provided by each of the subcircuits along a vector defined by the substrate. In this manner, interleaving the subcircuits along the vector of the substrate can provide separation between charge collection nodes without requiring increases in size. Thus, the flip-flop can be more compact and less expensive to manufacture.

Abstract: The present invention relates to new auristatin compounds and prodrugs thereof, compositions comprising them and uses thereof.

Abstract: The disclosure relates generally to sequential state elements (SSEs), triple-mode redundant state machines (TMRSMs), and methods and systems for testing triple-mode redundant pipeline stages (TMRPSs) within the TMRSMs using triple-mode redundant SSEs (TMRSSEs). The SSEs, TMRSMs, TMRPSs, and TMRSSEs may be formed as integrated circuits on a semiconductor substrate. Of particular focus in this disclosure are SSEs used to sample and hold bit states. Embodiments of the SSEs have a self-correcting mechanism to protect against radiation-induced soft errors. The SSE may be provided in a pipeline circuit of a TMRSM to receive and store a bit state of a bit signal generated by combinational circuits within the pipeline circuit. More specifically, the SSEs may be provided in a TMRSSE configured to perform self-correction. Also disclosed are methods for using the TMRSSE to test redundant pipeline stages of the TMRSM.

Abstract: Some embodiments include an imaging system. The image sensor array includes multiple image sensor sheets configured in an array grid. Each image sensor sheet of the multiple image sensor sheets can include a flexible substrate layer, and the flexible substrate layer can include a first flexible substrate side and a second flexible substrate side opposite the first flexible substrate side. Meanwhile, each image sensor sheet of the multiple sensor sheets can include multiple image sensors over the first flexible substrate side, the multiple image sensors can include multiple flat panel image detectors configured in a sheet grid, and the image sensor array can include an approximately constant pixel pitch. Other embodiments of related systems and methods are also disclosed.

Abstract: Provided are methods for performing patterned chemistry and arrays prepared thereby.

Abstract: Embodiments of complementary biasing circuits and related methods are described herein. Other embodiments and related implementations are also disclosed herein.

Abstract: Substrates may be bonded according to a method comprising contacting a first bonding surface of a first substrate with a second bonding surface of a second substrate to form an assembly; and compressing the assembly in the presence of an oxidizing atmosphere under suitable conditions to form a bonding layer between the first and second surfaces, wherein the first bonding surface comprises a polarized surface layer; the second bonding surface comprises a hydrophilic surface layer; the first and second bonding surfaces are different.

Abstract: The present invention relates generally to dendritic metal structures and devices including them. The present invention also relates particularly to methods for making dendritic metal structures without the use of solid electrolyte materials. In one aspect, a method for constructing a dendritic metal structure includes providing a substrate having a surface and a cathode disposed on the surface; providing an anode comprising a metal; and disposing a liquid on the surface of the substrate, such that the liquid is in electrical contact with the anode and the cathode; and then applying a bias voltage across the cathode and the anode sufficient to grow the dendritic metal structure extending from the cathode. The methods described herein can be used to grow dendritic metal electrodes, which can be useful in devices such as LEDs, touchscreens, solar cells and photodetectors.

Abstract: In some embodiments, a method of manufacturing electronic devices including providing a carrier substrate having a first side, a second side, and a first adhesive at the first side; providing a first flexible substrate; and bonding the first flexible substrate to the first side of the carrier substrate. The first adhesive bonds the first flexible substrate to the first side of the carrier substrate. The carrier substrate comprises a mechanism configured to compensate for a deformation of the carrier substrate. Other embodiments are disclosed.

Abstract: The present disclosure relates to solid polymer electrolytes, prepolymer compositions, and their uses in the preparation of capacitors.

Abstract: A microfluidic device useable for performing live cell computed tomography imaging is fabricated with a cover portion including a first wafer with at least one metal patterned thereon, a base portion including a second wafer with at least one metal patterned thereon and negative photoresist defining recesses therein, and a diffusive bonding layer including a negative photoresist arranged to join the cover portion and the base portion. A composition useful in live cell computer topography includes a long-chain polysaccharide at a concentration of from about 0.01% to about 10.0% in cell culture medium for supporting cell life while enabling cell rotation rate to be slowed to a speed commensurate with low light level imaging.

Abstract: A device for reading the sequence of a polymer, consisting of a first electrode and a second electrode, each electrode being functionalized with a reader molecule strongly bonded to the electrodes, but forming weak bonds with a molecule to be sequenced. In particular, the reader molecule is designed to form bonds with at least two points on the target molecule such that the target molecule is trapped between a first reader molecule on one electrode and a second reader molecule on the second electrode, with the overall size of the molecular complex being small enough to permit significant electric current to flow.

Abstract: The present invention provides reagents and methods for biomaterial production from cyanobacteria.

Abstract: The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.

Abstract: Designs and operations of momentum antennas are presented. In some antenna designs, the terminating discontinuities are complementary with the opposite transmission line's discontinuity. In other antenna designs, the terminating discontinuities are intrinsically self-complementary.

Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof: compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

Abstract: Examples disclose a method, executable by a processor, to assign a metric of vulnerability to a virtual machine. Based on the metric of vulnerability, the method places the virtual machine into a detection phase. Additionally, the examples disclose the method is to receive an alert corresponding to the virtual machine and based this received alert, the method implements a countermeasure.

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

Abstract: Some embodiments include an apparatus for testing flexible displays. The apparatus can include: (a) a first clamp configured to receive a first end of the flexible display; (b) a second clamp configured to receive a second end of the flexible display, wherein the second end of the flexible display is opposite the first end of the flexible display; and (c) a test column. Other embodiments and methods are disclosed herein.

Abstract: The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.