Abstract: Novel wortmannin analogs and their use in inhibiting PI-3-kinase activity in mammals and the treatment or prevention of cancer and tumor formation in a subject are described herein. Preferably, the wortmannin analogs may be administered with other chemotherapeutic agents in the treatment of cancer.
Type:
Application
Filed:
September 23, 2008
Publication date:
April 2, 2009
Applicants:
Prolx Pharmaceuticals Corp., Arizona Board of Regents, acting on hehalf of The University of Arizona, The University of Pittsburgh
Inventors:
Lynn Kirkpatrick, Garth Powis, Peter Wipf