Abstract: The present invention provides certain polymeric materials, precursors thereof as well as the preparation and uses thereof.

Abstract: A versatile space telescope for quantum key distribution and adapted for interfacing with a spacecraft and an instrument module. The telescope includes diamond turned aluminum mirrors at its entrance and exit, adjacent the spacecraft and instrument module, respectively.

Abstract: Methods of vulcanization using a high content sulfur polymer, instead of elemental sulfur, have been developed. These high sulfur content polymers are referred to as Chalcogenide Hybrid Inorganic/Organic Polymers (CHIP) materials and have good polymer compatibility in that they are soluble in a number of polymers. Furthermore, CHIP materials may have weaker bonds than the S—S bonds of elemental sulfur and thus provide for a higher crosslinking efficiency vulcanization.

Abstract: Methods for identifying animals that are genetically superior, drugs, nutritional strategies, or physiological manipulations that improve feed efficiency or productivity of animals, e.g., selecting animals that are genetically superior for feed efficiency or productivity based on metabolic rates of particular tissues, wherein metabolic rates of certain tissues such as skeletal muscle are inversely proportional to feed efficiency, while metabolic rates of other tissues such as mammary gland are directly proportional to milk production. Thus, animals with low skeletal muscle metabolic rates are generally more feed efficient, e.g., gain more weight per unit of food. The methods herein may be used to improve the genetics, nutrition, and handling or animals more efficiently produced animal products, e.g., meat production, milk, production, egg production, wool production, etc. The methods herein may also be used to determine estimated breeding values of animals for feed efficiency, growth, or production.

Abstract: An optical device is provided that comprises a multi-order diffractive Fresnel lens (MOD-DFL) and an achromatizing compensation mechanism that reduces refractive dispersion created by the MOD-DFL, thereby reducing the focal range of the MOD-DFL. A method is also provided of using the optical device in an image processing system to obtain images of an object and processing the images to perform image enhancement.

Abstract: Provided herein are compositions and methods for treating pulmonary arterial hypertension. In particular, provided herein are dry powder formulations of TMP for delivery to the lung.

Abstract: Provided herein are systems and method for measuring cell stiffness. In particular, provided herein are microelectrode configuration and systems for measuring platelet deformation and stiffness.

Abstract: Various examples are provided related to determination of contact angle of sessile drops. In one example, a method includes determining a volume of a sessile drop of fluid disposed on a test surface; determining a height of the sessile drop of fluid; and determining a contact angle of the sessile drop of fluid based upon the volume and the height of the sessile drop. In another example, a system includes a volume sensing, a height sensing, and computing that can determine a volume and height of a sessile drop using volume and height data from the sensing, and determine a contact angle of the sessile drop with the volume and the height. The contact angle and surface tension can be determined with at least three of volume, a height, a footprint radius, a radius of maximum horizontal extent, and/or an apex radius of curvature of the drop.

Abstract: Disclosed are methods and systems for detecting RNA and sequencing RNA in a wide range of samples such as samples with low concentrations of nucleic acid, samples with degraded nucleic acid, samples that would not otherwise be amenable to conventional sequencing or RNA detection methods, poor quality samples, high quality samples in which rare mutations are sought, formalin-fixed paraffin-embedded samples, blood samples, etc. The methods of the present invention may use paired, large panels of primers to amplify many short fragments that overlap between but not within each panel. Each panel's amplicon set may fill the gaps between those of the opposing panel, thereby providing complete gene or genomic coverage. A preliminary, multiplex amplification step amplifies target nucleic acid for all downstream reactions such as Sanger sequencing, cloning, and Next Generation Sequencing (NGS).

Abstract: Patterned polarizers with reduced transition regions are formed using a directional etch. Multiple layers can be combined to produce filters for polarization cameras and displays as well as achromatic filters.

Abstract: Metallopolymers composed of polymers and catalytically active diiron-disulfide ([2Fe-2S]) complexes are described herein. [FeFe]-hydrogenase mimics have been synthesized and used to initiate polymerization of various monomers to generate metallopolymers containing active [2Fe-2S] sites which serve as catalysts for a hydrogen evolution reaction (HER). Vinylic monomers with polar groups provided water solubility relevant for large scale hydrogen production, leveraging the supramolecular architecture to improve catalysis. Metallopolymeric electrocatalysts displayed high turnover frequency and low overpotential in aqueous media as well as aerobic stability. Metallopolymeric photocatalysts incorporated P3HT ligands to serve as a photosensitizer to promote photoinduced electron transfer to the active complex.

Abstract: A method for measuring distorted illumination patterns and correcting image artifacts in structured illumination microscopy. The method includes the steps of generating an illumination pattern by interfering multiple beams, modulating a scanning speed or an intensity of a scanning laser, or projecting a mask onto an object; taking multiple exposures of the object with the illumination pattern shifting in phase; and applying Fourier transform to the multiple exposures to produce multiple raw images. Thereafter, the multiple raw images are used to form and then solve a linear equation set to obtain multiple portions of a Fourier space image of the object. A circular 2-D low pass filter and a Fourier Transform are then applied to the portions. A pattern distortion phase map is calculated and then corrected by making a coefficient matrix of the linear equation set varying in phase, which is solved in the spatial domain.

Abstract: A beam steering apparatus including a first actuatable micromirror array (AMA) having a pitch, p, adapted to impart a modulation to a wavefront incident on the first AMA by a transition between a first state and a second state, wherein the first AMA has a transition time (T) between the first state and the second state, and at least one light source adapted to provide the incident wavefront having a duration, t, to the first AMA, where t?T. The AMA may be a MEMS device such as a digital micromirror array. The beam steering apparatus may constitute a portion of LIDAR system.

Abstract: A method for preparing 18F radiolabeled biomolecules and agents for 18F-PET imaging is disclosed herein. A perfluoroaryl-conjugated target tracer is synthesized and purified with temperature and solvent conditions that are mild for the tracer molecule. The purified perfluoroaryl-conjugated target tracer is then labeled with 18F using 18F salts within a short reaction time, and with temperature and solvent conditions that are mild for the tracer molecule. The method provides a quick and convenient process that maintains the biological activities of the target molecules. The radio-labeled biomolecules may be used as contrast agents for Positron Emission Tomography (PET).

Abstract: Various examples are provided related to amplified deformable mirrors (ADMs). In one embodiment, an ADM includes a deformable mirror and a flexible dielectric matrix deposited on a front side of the deformable mirror. A pathlength of a wavelength, ?0, of electromagnetic radiation passing through the dielectric matrix can be amplified by a distribution of dielectric particles embedded in the dielectric matrix.

Abstract: Features are described for a pellet dispenser. The pellet dispenser be implemented as a complex molded unit to fit within the home cage of laboratory animals (e.g., hanging from a wall of the cage or inside a food hopper of the cage). The pellet dispenser may be contained within the cage or otherwise attached to the cage so as not to take up additional floor space in the cage which should be allocated for the small laboratory animal. The pellets may be gravity or screw drive fed towards an ejector port. At prescribed times during the day, a prescribed number of pellets may be ejected into the animal cage. Additional components of the pellet dispenser include an ejector (e.g., a linear actuator) and pellet hopper.

Abstract: Viral promoters and compositions and methods of use thereof are provided. Compositions include viruses with impaired ability to reactivate from latency, and pharmaceutical compositions and method of use thereof. The genome of the viruses include one or more mutations that reduce expression from one or more promoters that regulate expression of viral genes during reactivation from latency. The mutation(s) are typically in a region of the viral genome that includes (i) promoter elements of the iP1 promoter of human cytomegalovirus, or the sequence of another virus corresponding thereto (e.g., an iP1 promoter homolog); (ii) promoter elements of the iP2 promoter of human cytomegalovirus, or sequence of another virus corresponding thereto (e.g., an iP2 promoter homolog); or (iii) a combination thereof. In some embodiments the virus encodes one or more heterologous antigens. The viruses can be used as vaccines to induce prophylactic and therapeutic immune responses in subjects in need thereof.

Abstract: Minimally invasive percutaneous methods, devices, and systems for placing guide wires in bones in a desired position and orientation and for facilitating the treatment of fractures such as but not limited to intertrochanteric fractures or other applications such as osteotomies. The methods, devices, and systems may allow for rapid and reproducible placement of a guide wire in a bone. Each degree of freedom may be controlled independently.

Abstract: A composition includes a reaction product of a mixture of elemental sulfur and at least a first ethylenically unsaturated compound comprising a hydroxyl or carboxyl group.

Abstract: Devices and systems for treating based on light therapy are disclosed. One example device includes an eyewear configured for placement in front of an eye to allow light to reach the eye, and one or more filters having transmission spectra within a range that approximately spans 450 to 570 nm associated with blue or green light. The one or more filters is configured to block light spectra outside of said range and to allow the blue or green light to reach the eye for administering light therapy to a subject exhibiting pain.