Abstract: An error correction and fault tolerance method and system for an array of disks is presented. The array comprises k+5 disks, where k disks store user data and 5 disks store computed parity. The present invention further comprises a method and a system for reconstituting the original content of each of the k+5 disks, when up to 5 disks have been lost, wherein the number of disks at unknown locations is E and the number of disks wherein the location of the disks is known is Z. All combinations of faulty disks wherein Z+2×E?4 are reconstituted. Some combinations of faulty disks wherein Z+2×E?5 are either reconstituted, or errors are limited to a small list.

Abstract: A lithographic method for making an out-of-plane optical coupler includes forming a photoresist layer of positive photoresist material over a substrate. The positive photoresist layer undergoes a flood exposure to light through a binary mask to pattern a latent image of a mirror blank in the photoresist layer. A laser beam is scanned over the latent image of the mirror blank to apply controlled dosages of light at specified locations to form a latent image of a planar mirror surface that is oriented at a prescribed non-zero angle to a plane in which the substrate extends. The positive photoresist material is developed so that a remaining portion of the developed positive photoresist material forms an out-of-plane optical coupler having a planar mirror surface that is oriented at the prescribed angle.

Abstract: The present invention provides a method of calibrating gamma-ray and photon counting detectors, including, but not limited to, monolithic crystal detectors. The method of the present invention is based on the observation that measurement of fan beam datasets allows the synthesis of collimated beam data to derive MDRFs by use of an algorithm that finds the common or intersecting data subsets of two or more orthogonal calibration datasets. This makes the calibration process very efficient while still allowing the full benefits of maximum-likelihood event-parameter estimation that incorporates the statistical nature of the light sensor measurements.

Abstract: Methods and devices for measuring full or partial Mueller matrix information in a single shot are described. One single shot polarimeter includes a polarization filter that is positioned to receive collimated light from a light source and to produce light having different polarization states. The polarization filter includes at least four sections, where each section receives a portion of the collimated light and produces light of a particular polarization state, which is spatially separated from light produced by other sections of the polarization filter. An imaging component images the sections of the polarization filter onto a plane of a sample object. One or more optical elements receive the light from the sample object and image a section of the sample object onto a detector. The disclosed devices and methods enable the measurement of the Mueller matrix of the sample with high signal-to-noise ratios.

Abstract: A mobile augmented reality near to eye display having one of a single chip programmed, configured, or adapted to permit user selective field of view and a variable resolution image projection, or a single image guide adapted to multiplexed full color image transfer to achieve full color, 90 degrees FOV, and retinal image resolution.

Abstract: This present invention is directed to variable affinity chromatography apparatus and methods for using the same. In particular, the polarity of the stationary phase or the mobile phase is modulated using an external stimulus. Exemplary external stimulus that can be used in the invention include, but are not limited to, electric field, electromagnetic radiation including UV, Vis, and infrared wavelengths, as well other stimuli that are known to one skilled in the art. Generally, any external stimulation that changes the polarity of a stimulus responsive material can be used.

Abstract: The present invention provides compositions and methods for determining a saccharide level in a sample. In particular, compositions and methods of the invention include a boronic acid moiety that forms a complex with a saccharide.

Abstract: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.

Abstract: In an example, a computer-implemented method to structure an analytical workflow that improves reasoning based on a problem context and demonstrated abilities of each individual user may include displaying a reasoning problem to an analyst. The method may include receiving input from the analyst to identify a reasoning problem type of the reasoning problem. providing a recommended analytic approach for the reasoning problem type to the analyst. The method may include assisting the analyst in analyzing and evaluating one or more information sources relevant to the reasoning problem. The method may include guiding the analyst through a structured technique (ST) to support reasoning of the analyst in formulation of a solution to the reasoning problem. The method may include generating a report that includes the analyst's solution to the reasoning problem based on input from the analyst.

Abstract: A light projection system comprising a light modulator that comprises a plurality of pixels each capable of selectively directing a corresponding modulatable amount of light, and a processor coupled to the light modulator to control the amount of light output from each of the plurality of pixels. The processor is configured to control the light modulator to form a computer generated hologram (CGH) wavefront from the light modulator corresponding to an image to be produced in the far field. The processor is also configured to control the light modulator to selectively direct the CGH wavefront. The light modulator may comprise an angular light modulator (ALM) comprising the plurality of pixels, each of the plurality of pixels having an OFF state and an ON state, the ALM arranged to direct the amounts of light in the direction as the pixels transition between the ON state and the OFF state.

Abstract: Methods for quality control and optimizing the formation and characterization of micelles, vesicles or other aggregates are described herein. Pharmaceutically relevant peptides may be modified to form glycopeptide surfactants which form micelles or other aggregates with another surfactant. Glycopeptide and glycolipid surfactants can aggregate to form particles that enhance drug delivery. The glycopeptide surfactants may be drugs or pro-drugs which are delivered via the micelles or other aggregated structures.

Abstract: A light projection system, including a light source to provide an output beam of light, an angular light modulator (ALM) comprising a plurality of pixels, each pixel having an ON state and an OFF state, the ALM positioned to receive output beam on the plurality of pixels, and a processor coupled to the ALM. The processor is programmed to control a first set of the pixels to transition between the OFF state and the ON state while the beam is incident on the pixels. An amount of light is selectively directed in a direction by the first set. The processor is also programmed to control a second set of the plurality of pixels to remain in the OFF state while the beam is incident on the plurality of pixels. As a result, the ALM operates as a spatial light modulator and an angular light modulator of the beam of light.

Abstract: Methods, apparatus and systems for achieving efficient optical design are described. In one representative aspect, a method for optical design includes introducing a light source into the optical system. The light source emits illumination that is characterized as a point source, a collimated illumination, or a superposition of one or more point sources or one or more collimated illuminations. The light source is represented by a vector field comprising a plurality of vectors. The method also includes defining each optical surface of the optical system based on the vector field of the light source, tracing a plurality of rays that propagate from the light source, traverse through the optical system and reach a predetermined target or targets, and determining whether an illumination or an image characteristic at the predetermined target or targets meets preset design requirements.

Abstract: A method of interrogating a WDM optical communication system is provided to obtain one or more performance parameters. In accordance with the method, an optical probe wavelength is generated and possibly modulated in a prescribed manner. The probe signal is transmitted along a selected optical path through the WDM optical communication system for a duration of time that is less than a response time of network elements that impact signal quality along the selected optical path.

Abstract: Coccidioidomycosis is most often diagnosed serologically and the quantitative complement-fixing antibody test (CF) is considered prognostically useful. Because CF is complex, labor-intensive, and poorly standardized, an enzyme-linked immunoassay (ELISA) alternative would be attractive. The present invention features an antibody-binding domain that is restricted to a 200 amino acid recombinant peptide of the known antigen responsible for CF activity. Overlapping truncations of this peptide do not bind CF antibodies, suggesting that the responsible epitope(s) are conformational. Further, anchoring the antigenic peptide to the ELISA plate by means of a C-terminal tag instead of allowing the peptide to randomly adhere to the plastic plate improves sensitivity of antibody detection by one to two logs in different sera. The newly developed ELISA shows a significant quantitative correlation with CF. This ELISA shows potential as the basis for a new quantitative assay for coccidioidal antibodies.

Abstract: A gaze tracking platform for human-machine interface device, such as a wearable Augmented Reality Near-to-Eye Display. The gaze tracking method, digital illumination assisted analog feedback tracking employs neither auxiliary camera nor digital image processing of human eye image that confronts challenges in gaze tracking speed, power, cost and space. Instead, an analog-digital hybrid method to track the gaze inspired by the groove tracking method that is widely adopted for optical data storage systems. In the method, a digital micromirror device generates angular modulated and infrared illuminating beam. The cornea reflects the infrared light and a segmented photodiode detects the reflection while providing a feedback servo signal to the digital micromirror device controller. The feedback signal is integrated over a time provides the variation gaze. Moreover, infrared and angularly modulated illumination is time-multiplexed with information displayed in visible wavelength.

Abstract: A heliostat includes a reflecting surface; an elastically deformable frame on which the reflecting surface is mounted; a truss structure behind the elastically deformable frame that includes at least four bracing struts with first ends attached to the elastically deformable frame and second ends attached to at least one node located centrally behind the frame; at least one actuator connected to at least one of the at least four struts at the at least one node; an electronic control system configured to communicate with the least one actuator; and a dual-axis mount to support and orient the above assembly. The actuation of the at least one actuator in response to the electronic control system causes compression or tension of at least one of the at least four bracing struts to thereby control a shape of the reflecting surface and the elastically deformable frame in at least low order bending modes.

Abstract: The present disclosure relates to systems and methods for translating optical beams.

Abstract: The present invention features methods, systems, and compositions for inhibiting function of EspZ or an EspZ equivalent, and for inhibiting or reducing virulence of pathogens that utilize EspZ or EspZ equivalent, such as those pathogens that belong to the attaching-effacing (A/E) family. The methods may feature the use of an inhibitor peptide that targets at least a portion of EspZ, such as one of the transmembrane domains. In certain embodiments, the inhibitor peptide disrupts proper dimerization or oligomerization of EspZ.

Abstract: A controller to communications between a baseband unit (BBU) and a remote radio head (RRH) in a mobile fronthaul (MFH) network. The controller to initialize a pseudorandom seeding in the BBU and RRH and to cause the BBU and RRH to generate a pair of matching pseudorandom bit sequences (PRBS) to enable the BBU and RRH to synchronize communications therebetween; to select a wavelength and to select a route, through the MFH network, to enable the BBU and RRH to communicate using the selected wavelength and route; to select an error correction code and a modulation format for communications between the BBU and RRH; to encode one or more parameters of a physical layer in the MFH network into the PRBS; and to monitor a data stream between the BBU and RRH to determine if a bit error rate has changed for each frame of the data stream.