Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperidinyl-benzoimidazole structure which function as antagonists of small ubiquitin like modifier (SUMO) related modification (SUMOylation) of collapsin response mediator protein 2 (CRMP2), and their use as therapeutics for the treatment of voltage gated sodium channel 1.7 (Nav1.7) related itch, anosmia, migraine event, and/or pain (e.g., neuropathic pain).

Abstract: Disclosed is CT or MR contrast agent which comprises a base or carrier scaffold formed of a polyhydroxol compound having a linker to which a Gd-DOTA is covalently bonded. Also disclosed is a method of screening a patient for colon cancer using a CT or MR contrast, which method comprises administering to a patient undergoing screening a compound as above described.

Abstract: An imaging system and method for detecting a target in a sample. The imaging system includes a lens-free holographic microscope having a light source in a first plane spaced above an image sensor. The image sensor extends in a second plane. The system also includes a microfluidic chip positioned between the light source and the image sensor. The microfluidic chip extends in a third plane, which is parallel to the second plane. There is at least one chamber in the microfluidic chip configured to receive a sample solution with a target. The system also has a plurality of functionalized beads positioned within the at least one chamber in the microfluidic chip. Any two of the plurality of functionalized beads have an affinity for binding together when exposed to the target in the sample solution.

Abstract: A kinematically engaged yoke system (KEYS) for multiple-order-diffraction engineered material may comprise a harness comprising a frame and a plurality of semi-kinematic keys disposed on the frame, wherein the semi-kinematic keys are configured based on a MOD-side mechanical profile of a plurality of segments of a multiple-order-diffraction engineered material, and wherein the MOD-side mechanical profile, when engaged with the semi-kinematic keys, functions as a fiducial that provides alignment between neighboring segments; and one or more shims disposed between one or more pairs of neighboring segments of the plurality of segments of the multiple-order-diffraction engineered material, wherein the one or more shims facilitate alignment of the one or more pairs of neighboring segments of the plurality of segments based on a translation across one or more surfaces of the one or more shims.

Abstract: Night vision systems that are compact in size due to one or more of the design of the optical system and light detector module.

Abstract: The present disclosure provides immunogenic compositions against Campylobacter and methods for using the immunogenic composition to generate an immune response against Campylobacter and/or reduce intestinal colonization by Campylobacter.

Abstract: Methods, systems, and devices for regulating blood glucose such as implantable encapsulated devices optionally with insulin and/or glucagon secreting cells in combination with glucose sensors and insulin infusion systems. For example, encapsulation devices may be connected to an insulin infusion pump for distribution of insulin. The insulin infusion pump may feature an insulin pouch fluidly connected to an insulin pump (or a syringe) and a glucose sensor separate from the encapsulation device. The system may feature an additional implantable device comprising insulin and glucagon secreting cells.

Abstract: Disclosed are fast gamma-ray interaction-position estimation methods using k-d tree searching. Compared with conventional methods, the methods disclosed herein achieve both high levels of speed and accuracy using k-d tree data structures. The k-d tree search methods have a time complexity of O(log x(N)), where x is the number of branches at each node and N is the number of entries in the reference data set, which means larger reference datasets can be used to efficiently estimate each event's interaction position. The accuracy of methods described herein was found to be equal to the exhaustive search method, yielding the highest achievable accuracy. Most importantly, the disclosed methods have no restriction on the data structure of the reference dataset and can work with complicated mean detector response functions (MDRFs), meaning it is more robust compared with other methods such as contracting grid (CG) search or vector search (VS) methods.

Abstract: A diffractive multifocal lens is disclosed, comprising an optical element having at least one diffractive surface, the surface profile comprising a plurality of annular concentric zones. The optical thickness of the surface profile changes monotonically with radius within each zone, while a distinct step in optical thickness at the junction between adjacent zones defines a step height. The step heights for respective zones may differ from one zone to another periodically so as to tailor diffraction order efficiencies of the optical element. In one example of a trifocal lens, step heights alternate between two values, the even-numbered step heights being lower than the odd-numbered step heights.

Abstract: Methods, devices and systems provide improved spectral imaging and detection and can be implemented as compact, light-weight and low-cost devices. An example device includes a mask that includes a plurality of apertures and positioned to receive light from an object of interest. A first lenslet array is positioned to receive light that passes through the plurality of apertures. Each lenslet of the first lenslet array receives the light from a corresponding aperture and produces collimated light that is incident on a dispersive element, such as a diffraction grating or a prism, which produces a plurality of spectrally separated components. A second lenslet array receives the spectrally separated components and focuses each of the spectrally separated components onto an image plane, where a sensor is located. The information obtained from the sensor can be used to determine or analyze spectral characteristics of the object, which can be in gaseous form.

Abstract: Compositions and methods that utilize a combination of essential oils or other plant-derived extracts or compounds and an emulsifier as an antimicrobial are provided. In some embodiments the compositions further include ozone. In some embodiments, the composition includes one or more plant essential oils, plant extracts, or plant-derived compounds, or combinations thereof, and an emulsifier (such as a saponin). The antimicrobial composition may also include water, peracetic acid, acetic acid, lactic acid, citric acid, and/or hydrogen peroxide. Methods of killing a microorganism, including contacting the microorganism with the disclosed antimicrobial compositions are also provided. The microorganism may be present on a food item or a food contact of non-food contact surface and may be in the form of a biofilm. In some examples, the antimicrobial composition is used one or more times (such as 1 to 5 times).

Abstract: Systems, methods and software products determine an overall motion and/or flexibility envelope for an individual. Movement and position data of the individual is captured and processed to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual. The systems include a flexibility server with memory and a processor adapted to receive movement and position data of the individual, a motion and/or flexibility analyzer, implemented as machine readable instructions stored in the memory and executed by the digital processor, capable of processing the movement and position data to generate an overall motion and/or flexibility envelope for the individual defining overall motion and/or flexibility of the individual.

Abstract: Eye-tracked head-mounted displays are provide which, in one aspect, may utilize the same optics for eyetracking and image viewing, with a selected portion of the optics used for an eyetracking optical path and a selected portion of the display optics used for an image viewing optical path.

Abstract: An apparatus for generating electricity from solar energy has a large dish reflector with a fly's eye receiver positioned near the focus of the dish reflector, held by a dual axis tracking structure. The fly's eye receiver includes a field lens that concentrates sunlight into an image of the dish reflector, a two-dimensional fly's eye array of contiguous convex lenses extending across the dish image, and a photovoltaic cell behind each convex lens of the fly's eye array. Two imaging stages are provided. First, the dish reflector and the field lens concentrate the sunlight in the form of an image of the dish that is stabilized against pointing errors of the tracking mechanism. Second, the contiguous array of convex lenses divides the sunlight energy of the dish image into portions, one per convex lens, each portion being further concentrated by the respective convex lens onto a corresponding photovoltaic cell.

Abstract: Apparatus and methods are disclosed for providing virtual bags that can be used to simulate and quantify performance of different explosive detection system architectures. The virtual bags can be provided to a simulator for designing and simulating operation of imaging scanners, including X-ray and millimeter-wave based threat detection equipment deployed in transit facilities and other secure locations. One example method of generating container models for a container inspection system includes generating a plurality of objects using a probability function; generating a respective position, scale, and orientation for each of the objects within a container having a defined boundary; generating pairings for a respective material for each of the objects using a probability function; and storing a container instance indicating at least one of: the generated pairings, the respective object positions, object scales, object orientation, the objects, or the respective materials in a computer-readable storage device.

Abstract: A spherical reflector antenna, including a sphere with a reflective surface opposite a transparent surface, a feed system that receives electromagnetic waves that (pass through the transparent surface at a beam angle) and are reflected off the reflective surface at a beam angle and outputs electromagnetic waves that are reflected off the reflective surface (and pass through the transparent surface at a beam angle), and beam steering electronics that identify a position of the spherical reflector antenna, identify an orientation of the sphere, and adjust the beam angle of the feed system based on angle from the position of spherical reflector antenna to the target relative to the orientation of the sphere.

Abstract: A photovoltaic (“PV”) module may comprise an array of freeform micro-optics and an array of PV cells. The PV module may be a flat panel with a nominal thickness smaller than the length and width of the flat panel. An array of lenses may be embedded in an array substrate. The lenses may be coupled to light pipes. The lenses may concentrate light through the light pipes to multi-junction cells. Diffuse light may be transferred through the array substrate to a silicon cell. The lenses and light pipes may be manufactured using a molding and drawing process.

Abstract: An athermal optical waveguide structure such as an optical add drop multiplexer (OADM) or the like is fabricated by a method that includes forming a lower cladding layer on a substrate. A waveguiding core layer is formed on the lower cladding layer. An upper cladding layer is formed on the waveguiding core layer and the lower cladding layer a sol-gel material. The sol-gel material includes an organically modified siloxane and a metal oxide. A thermo-optic coefficient of the sol-gel material is adjusted by curing the sol-gel material for a selected duration of time at a selected temperature such that the thermo-optic coefficient of the sol-gel material compensates for a thermo-optic coefficient of at least the waveguiding core layer such that an effective thermo-optic coefficient of the optical waveguide structure at a specified optical wavelength and over a specified temperature range is reduced.

Abstract: Biopolymer compositions comprising antimicrobial peptides (AMPs) for treating infections such as bacterial infections, viral infections, fungal infections, and parasitic infections. The compositions herein may also be used for treating infections associated with antibiotic-resistant bacteria, antifungal-resistant fungi, antiviral-resistant viruses, or for treating biological warfare agents (BWAs) such as Bacillus anthracis and Yersenia pestis. The present invention also provides methods of synthesis of said biopolymer compositions, wherein AMP biopolymers can be synthesized as an artificially engineered protein by genetically fusing an AMP; a protein that behaves similarly to polymer tethers; and a protein as a modifiable material platform that can transform to self-assembled nanoparticles, self-standing films, or adhesives to easily attach tethered AMPs onto any biomaterial surface for various clinical applications.

Abstract: Methods, devices and systems are disclosed that enable accurate and reliable measurements of wavefront aberrations with a wide dynamic range. The described wavefront sensors can be implemented at a low cost and without any moving parts. One wavefront sensor includes an optical pyramid positioned to receive a focused incoming light beam. The optical pyramid includes three facets that each allow a portion of the focused incoming light beam to exit the optical pyramid. The wavefront sensor also includes one or more imaging lenses positioned to receive light that exits each of the facets of the optical pyramid, and one or more lenslet arrays positioned to receive light from the one or more imaging lenses and to produce a plurality of focused light spots corresponding to each lenslet of the lenslet array.