Patents Assigned to Arizona Board of Regents on Behalf of the University of Arzona
  • CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF
    Publication number: 20180289700
    Abstract: The present invention provides compounds that can modulate the amount of Nav 1.7 protein, a key protein in pain signaling, that is present in the cellular surface and methods for using such compounds. In particular, compounds of the invention modulate the amount of Nav 1.7 protein on the cellular surface by modulating SUMOylation of CRMP2. Thus, compounds of the invention can be used to treat various clinical conditions associated with the presence and/or activation of Nav 1.7 protein on the cellular surface and/or SUMOylation of CRMP2.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 11, 2018
    Applicant: Arizona Board of Regents on Behalf of the University of Arzona
    Inventors: May Khanna, Rajesh Khanna, Vijay Gokhale, Reena Chawla