Abstract: The present invention provides devices and methods to separate and concentrate target species. In some embodiments, a punctuated continuous microchannel or parallel processing (array-based) separations are provided, the microchannel having a plurality of sequential, constrictive insulating features to form a plurality of reservoirs including a first, second and third reservoir, and a plurality of constricted passageways including a first constricted passageway that connects the first reservoir to the second reservoir and a second constricted passageway that connects the second reservoir to the third reservoir. A voltage is applied to the microchannel to create different electrical fields and/or different dielectrophoresis (DEP) gradients at each of the plurality of constricted passageways in order to separate species that have differing ratios of electrokinetic mobility to dielectrophoretic mobility.
Type:
Application
Filed:
February 3, 2014
Publication date:
December 17, 2015
Applicant:
ARIZONA BORAD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Inventors:
Mark HAYES, Paul JONES, Stacy KENYON, Michael KEEBAUGH, Thomas TAYLOR, Prasun MAHANTI, Sarah STATON, Noah WEISS