Abstract: Embodiments of a system for reducing driver distraction and improving automobile safety are disclosed.

Abstract: Embodiments of a vehicular system with an L-shaped infotainment display for reducing driver distraction and improving safety are disclosed.

Abstract: Embodiments of a system for improving automobile safety are disclosed.

Abstract: Co-clustering based on generalized conceptual relationships can automatically detect story forms incorporating archetypes/targets and actions. Co-clustering can help in identifying similarities that exist in low-dimensional sub-spaces of sparse data such as textual paragraphs. Through co-clustering, the clusters themselves and their characteristic features are identifiable which can be useful in describing and summarizing their contents. The residual error of factorization with concept-based features is significantly lower than the error with prior keyword-based features. Qualitative evaluations also suggest that concept-based features yield more coherent, distinctive and interesting story forms compared to those produced by using prior keyword-based features.

Abstract: An array of magnetic nanoparticle (MNP) spin torque oscillators (STOs) is described. Each STO is comprised of a uniform, chemically synthesized, spherical nanoparticle which couples to current flowing along a surface. The particles are organized into an array by a self-assembly technique with uniform spacing and close proximity to allow strong electrical and magnetic coupling between particles. The coupling of the nanoparticles to the surface current drives the oscillations by spin-torque, and for phase locking and data input. The uniform, spherical shape of the particles allows the oscillations to be achieved at low currents and with low power dissipation. The MNP-STOs may be used as a basis for massively parallel computing, microwave oscillators, or other applications.

Abstract: Systems and methods for low-cost point-of-care immunoassay are provided. The system comprises an emitter, two optical interference filters, a microscope slide, a photodiode detector, a circuit, and a measuring unit. The detector is placed upon the second filter, the slide, the first filter, and then the emitter. The emitter comprises non-organic light emitting diodes (LEDs) or organic light emitting diodes (OLEDs) that emits light of a first color. The slide is spotted with biofluid from a patient. Biomarkers in the biofluid is bound with immobilized fluorophores that emit light of a second color when stimulated by the light of the first color. The first and second filters band-pass the light of the first and second colors, respectively. The detector detects light of the second color. The current outputted from the detector is converted into a relatively-large output voltage by a circuit. A measuring unit measures the ramp time of the output voltage.

Abstract: Wastewater sludge is treated by combining the sludge with a carbon-based dielectric additive that includes carbon to yield a modified sludge, irradiating the modified sludge with microwave radiation to yield a treated sludge, and providing the treated sludge to an anaerobic digester.

Abstract: Mitochondria-targeting potassium sensors and method(s) for making such sensors. The sensor shows a response to potassium and displays a 130-fold dynamic range of fluorescence intensity and high brightness. The sensors response to potassium concentrations was demonstrated to be unaffected by cellular pH value and/or concentrations of other ions. The sensors can be used for monitoring the mitochondrial potassium efflux/influx.

Abstract: Systems and methods for stimulating neural tissue are disclosed. An array of optically emissive pixels is configured to deliver light to the neural tissue of a subject. Individual pixels within the array can be addressed to selectively illuminate a portion of the neural tissue when a neurological event occurs. The system can also include an array of microelectrodes in electrical communication with the array of pixels and a power source. A biocompatible substrate can be used to support the microelectrodes pixels, and the power source. A microelectrode circuit and a pixel circuit can also be supported by the biocompatible substrate.

Abstract: Disclosed are methods and systems for modeling and controlling production of an oil and/or gas, for example from a shale reservoir. The modeling includes receiving data associated with a fluid reservoir, including a viscosity of a fluid in the reservoir and a radius of a pore in the reservoir, and not including a permeability of the reservoir. The resulting model includes a reservoir fluid drainage rate that is proportional to the fluid viscosity and a reservoir fluid drainage speed that is independent of the pore radius. The model may be used to control a pump which pumps a fluid into and/or out of the reservoir.

Abstract: The present invention is directed to a polymerase activity assay that produces a strong optical signal when a primer-template complex is extended to full-length product. The assay uses Cy3 as the molecular beacon and Iowa Black® RQ as the quencher. The signal-to-noise-ratio (STNR) of this donor-quencher pairing is ˜200-fold over background, which is considerably better than other donor-quencher pairs (STNRs ˜10-20-fold). The STNR allows for solution-based monitoring of polymerase activity. Because the sensor functions via Watson-Crick base pairing, the polymerase activity assay may also be used to evolve polymerases to accept xeno nucleic acids as substrates.

Abstract: Embodiments of the invention provide a method of forming a metal matrix composite including introducing a plurality of nanoparticles into a flow of metal material, and mixing of at least a partial portion of the flow of metal material with at least some of the plurality of nanoparticles to form a mixture of the metal material and at least some of the nanoparticles. The method further includes forming a metal matrix composite from the mixture, where the metal matrix composite includes a bulk region and an outer surface including a plurality of hydrophobic regions dispersed within a hydrophilic surface region. Further, the plurality of hydrophobic regions is formed or derived from the plurality of nanoparticles, and the hydrophobic regions have a first diameter, and an average spacing between the hydrophobic regions is a second diameter, where the first and second diameters are about 100 nm to 400 nm.

Abstract: A haptic display system may comprise an array of vibratory elements, each vibratory element having a natural frequency different from the natural frequency of every other vibratory element in the array, a voice coil coupled to the array to impart vibrational energy to the array, and a microcontroller coupled to the voice coil to drive the array.

Abstract: The present application provides arrays for use in immunosignaturing and quality control of such arrays. Also disclosed are peptide arrays and uses thereof for diagnostics, therapeutics and research.

Abstract: Systems and methods for multi-mode radiation hardened multi-core microprocessors are disclosed. In some embodiments, a triplicated circuit includes a first core logic, a second core logic, a third core logic, and bus arbitration and control circuitry. The triplicated circuit is configurable to operate in both a Triple-Modular Redundant (TMR) mode of operation and a multi-threaded mode of operation. In some embodiments, there is essentially no overhead in soft mode and low overhead (power only) in hard mode. In most applications, it is expected that portions of missions require very hard systems (e.g., landing) where a failure is catastrophic. However, other portions require essentially no hardening (digital signal processor and signal processing activities) but much better throughput. Consequently, there is a huge opportunity to develop computer processors with low overhead in soft mode and unprecedented hardness in hard mode.

Abstract: Methods and systems are described for sensing and recovery of a biological signal using generative-model-based compressive sensing. A transformation is applied to sparsify the quasi-periodic signal removing morphology parameters and leaving temporal parameters. The sparsified signal is sampled and the sampled signal data is transmitted to a base station. A homotopy recovery algorithm is applied to the received sampled signal data by the base station to recover the temporal parameters of the biological signal. Generative modelling is applied using previously captured morphology parameters to generate a reconstructed signal. Finally, the reconstructed signal is adjusted and scaled based on the recovered temporal parameters to provide a reconstructed signal that is diagnostically equivalent to the original biological signal.

Abstract: A method for inhibiting and/or treating cancer in a subject in need thereof is disclosed. The method can include administering to a subject an effective amount of an HSP90 inhibitor; and administering to the subject an effective amount of Granzyme A, thereby treating and/or inhibiting the cancer in the subject in need thereof. A composition including an effective amount of an HSP90 inhibitor and an effective amount of Granzyme A is also disclosed.

Abstract: A processor is configured with a learning framework to characterize the residuals of attribute information and its coherence with network information for improved anomaly detection.

Abstract: The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

Abstract: The present disclosure relates to methods and compositions suitable for changing metabolite levels in a subject in need thereof. In particular, this application provides methods and compositions for changing metabolite levels in a subject diagnosed with Autism Spectrum Disorder (ASD). Methods of preventing or treating an ASD in a subject thereof, as well as methods of selecting a treatment plan for treating an ASD in a subject are also provided.