Abstract: Analogues of cholecystokinin-8, which are receptor selective, vary from the normal hormone by alteration of at least one of the two, three or six position amino acids of the natural sequence.

Abstract: This invention relates to a protease inhibitor of the insect Manduca sexta, its purification, cloning of a DNA sequence encoding the inhibitor, modifications to change inhibitor specificity, transgenic plants carrying and expressing said DNA sequence and insect resistance conferred thereby on said transgenic plants.

Abstract: Disclosed is a cDNA clone isolated from a fat body cDNA library from the tobacco hornworm Manduca sexta, and the deduced amino acid sequence of the serine proteinase inhibitor encoded by the cDNA.

Abstract: The present invention relates to a method for the preparation of ultrafine oxide particles using organized reaction media. Integrated circuit (IC) densities have necessitated the use of ultrahigh purity process fluids in state of the art fabrication facilities. It is the purpose of the present invention to synthesize monodispersed submicron particles of some representative contaminants, such as ultrafine oxide particles, using organized reaction media, and study their characteristics in relation to their removal from process fluids.

Abstract: A crystallizer control method and apparatus that generate control signals to manipulated process parameters on the basis of on-line information derived from the measurement of the crystal population in a selected size range in the crystallizer slurry. According to one embodiment of the invention, a particle counter probe is immersed directly into the fines removal circuit of the crystallizer for on-line measurement of crystal population in the 16 to 32 micron size range. The data so collected are then used directly in a standard proportional controller apparatus to manipulate certain operating parameters, such as fines removal rate and feed rate, to effect the desired result. Applying this model-independent control method to a KCl crystallizer, the steady-state conditions of the crystal size distributions were reestablished after an upset in approximately half the time required when no control was applied.

Abstract: The present invention relates to a method for the preparation of a swine dysentary subunit vaccine. The swine dysentery subunit vaccine is composed of antigenic material harvested from the surface of an anaerobic spriochete, Treponema hyodysenteriae. The bacterial cells, previously grown in large volume (5-7 liters) in a bench-top fermentor, are harvested by centrifugation and washed vigorously in phosphate buffered saline. The bacterial cells are then removed by a second centrifugation and the supernatant retained. The supernatant contains a salt extract consisting of the antigenic material used in the vaccine. Once harvested, the salt extract is concentrated 100X. The salt extract has been shown to be immunogenic in pigs. Five to six week old pigs are hyperimmunized intramuscularly (IM) with the salt extract. Pigs vaccinated with the salt extract are protected against infection with Treponema hyodysenteriae.

Abstract: Cyclic disulfide and linear dynorphin Dyn A.sub.1-11 and dynorphin Dyn A.sub.1-13 analogs which are highly specific for .kappa. opioid receptors. These analogs are useful in pharmaceutical compositions and for the analysis of opioid receptor/ligand interactions.

Abstract: This invention discloses a composite electrostatic optical apparatus and methods of using in micro fabrication processes or similar processes requiring the use of optical columns provided with electron or ion beams. The composite optical apparatus includes a series of units, each having multiple electrodes, that combine to form a composite optical structure that when coupled to a power supply define a three-dimensional potential distribution function. The shape of the composite optical structure is determined by the geometrical shape of an individual electrode and the arrangement of electrodes around the z-axis that forms a unit. The composite optical apparatus may be placed in an optical column as an electrosttic deflector, as a focusing electrostatic lens or as both deflector and focusing lens, or any combination of them.

Abstract: This invention discloses a mobile intensive care patient handling apparatus that includes a specially designed framework member, a pallet member for supporting the framework member while in a commerical aircraft, framework restraint brackets to secure the framework to the pallet member, pallet restraint brackets to secure the pallet member to seat rails provided on commercial aircraft, said framework member is provided with an undercarriage adapted for containing life sustaining medical equipment and further adapted for being secured to both the framework restraint brackets and a conventional ambulance's patient cot restraint brackets. The patient handling apparatus can be designed according to any aviation authorities' design requirements including, structural design requirements for emergency landing conditions, structural design requirements for gust load factors, hardware fastening, structural bonding, size and shape design requirements.

Abstract: A new and distinct cultivar of Chrysanthemum cinerariaefolium known by the cultivar name Arizona, and particularly characterized by the combined characteristics of high pyrethrin content, environmental stress tolerance, uniform flower stalk extension and substantially erect growth.