Abstract: A method is provided, in which three-dimensional objects are manufactured by layer-wise solidifying powdery synthetic material by impact of electromagnetic or particle radiation, wherein the powdery synthetic material has an anti-microbial property so that the manufactured objects comprise surfaces having an anti-microbial effect. The anti-microbial property is achieved by additives which are present in each powder grain. Such additives can be noble metals, for example argent. The manufactured objects are mainly used in particular in the food industry and in medical engineering.