Patents Assigned to Arlington Scientific, Inc.
  • Oxidized cardiolipin and uses to detect cardiolipin antibodies
    Patent number: 9081009
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: July 14, 2015
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Arlington Scientific Inc.
    Inventors: Arnold R. Castro, Himanshu Champaklal Mody
  • Oxidized cardiolipin and uses to detect cardiolipin antibodies
    Patent number: 8778619
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: July 15, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Arlington Scientific Inc.
    Inventors: Arnold R. Castro, Himanshu Champaklal Mody
  • OXIDIZED CARDIOLIPIN AND USES TO DETECT CARDIOLIPIN ANTIBODIES
    Publication number: 20140087398
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized cardiolipin, alone or complexed with one or more attachment molecules, are useful to detect anti-lipoidal antibodies (such as IgG and IgM antibodies) in subjects, for example, when used in ELISA plates. ELISA plates are described that permit the detection of anti-lipoidal antibodies and that permit the co-detection of nontreponemal and treponemal antibodies in biological samples.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 27, 2014
    Applicants: Arlington Scientific, Inc., Government of the U.S.A. as Represented by the Secretary of the Dept. of Health and Human Service
    Inventors: Arnold R. Castro, Himanshu Champaklal Mody