Abstract: A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being contaminated with microorganisms. The platelets are then contacted to a fixative for a time sufficient to fix the platelets. After fixing, the platelets are preferably washed and dried to produce fixed-dried platelets. The step of contacting the platelets to a fixative is carried out for a time sufficient to kill some or all the of the contaminating microorganisms.
Type:
Grant
Filed:
September 12, 1997
Date of Patent:
April 6, 1999
Assignees:
The University of North Carolina at Chapel Hill, Armour Pharmaceutical, East Carolina University
Inventors:
Marjorie S. Read, Arthur P. Bode, Louis J. Summaria
Abstract: The Specification discloses an improved peristaltic Roller Pump for pumping fluids through a flexible tubing. First and second surge release radii are formed on a semicylindrical reaction wall to minimize back surge or fluctuations in pump line pressure as the pump rollers engage and disengage the reaction wall. Improved sloped or angles sweep vanes are provided in front of each roller for collecting the tubing and directing it through a discharge throat into the path of the oncoming roller thereby minimize jamming, kinking or other entanglement of small diameter tubing when used in a roller pump. A novel and inexpensive construction arrangement provides for quick simple and precise adjustment of both rollers simultaneously to enable the operator to quickly adjust the pump, or to disassemble the pump for cleaning or sterilization.
Abstract: A process of preparing a serum protein composition for intravenous application or administration, in which process, starting from a human blood protein solution, a stabilized, universally applicable preparation or composition is prepared which contains dissolved in an aqueous isotonic solution, such proteins in which the ratio of globulins and albumins corresponds substantially to that of the native blood serum, in the following steps:(a) fractionation of human blood plasma upon removal of coagulation factors according to a process known per se recovering thereby precipitates and supernatants of different fractionation steps,(b) mixing and resolving of precipitates of different fractionation steps, preferably the COHN-fractions IV, III-1 and III-2), in which blood proteins, especially albumin and globulins, are preserved in a native form, said precipitates mixed and resolved in a chemically and physiologically adapted solvent, said solvent eventually containing also supernatants of the fractionation steps,(c)