Abstract: This invention generally relates to the field of compounds and methods for enhanced cellular uptake. In particular, the invention relates to N-acetylgalactosamine compounds and their conjugates. Also provided are methods for the preparation of these molecules and possible uses thereof, in particular in medicine.
Type:
Grant
Filed:
August 1, 2024
Date of Patent:
March 11, 2025
Assignee:
ARNATAR THERAPEUTICS, INC
Inventors:
Derek Steiner, Xuehai Liang, Yangfeng Wang
Abstract: Disclosed herein are Advanced RNA Targeting (ARNATAR) dsRNA compounds targeting angiotensinogen (AGT). Such compounds are useful in methods for reducing expression of AGT and for therapeutically treating RAAS associated diseases, disorders and/or conditions, or symptoms thereof in a subject.
Type:
Grant
Filed:
June 21, 2024
Date of Patent:
March 11, 2025
Assignee:
ARNATAR THERAPEUTICS, INC
Inventors:
Yen Lieu, Lingdi Zhang, Xuehai Liang, Yanfeng Wang