Abstract: The present invention provides methods for analysing a urine sample from a subject comprising exposing the urine sample to a lysis buffer which is capable of releasing at least one biomarker from cells in the urine sample. The present invention further provides kits, devices, and apparatuses that can be used in these methods. Finally, the present invention provides methods for detecting the presence of a urological cancer in a subject comprising performing an assay on a sample from a subject to determine the concentration of an Mcm protein.
Type:
Application
Filed:
October 21, 2022
Publication date:
June 15, 2023
Applicant:
ARQUER DIAGNOSTICS LIMITED
Inventors:
David Nicholas MILLER-JONES, Jacqueline STOCKLEY, Cheryl NYBERG
Abstract: The present invention provides methods for analysing a urine sample from a subject comprising exposing the urine sample to a lysis buffer which is capable of releasing at least one biomarker from cells in the urine sample. The present invention further provides kits, devices, and apparatuses that can be used in these methods. Finally, the present invention provides methods for detecting the presence of a urological cancer in a subject comprising performing an assay on a sample from a subject to determine the concentration of an Mcm protein.
Type:
Grant
Filed:
June 1, 2016
Date of Patent:
December 6, 2022
Assignee:
ARQUER DIAGNOSTICS LIMITED
Inventors:
David Nicholas Miller-Jones, Jacqueline Stockley, Cheryl Nyberg
Abstract: The present invention relates to methods for detecting the presence of Mcm5 in a subject, the method comprising preparing a sample from said subject by exposing the sample to a lysis buffer and performing an assay to determine the concentration of Mcm5 by exposing the sample to a first monoclonal antibody and/or a second monoclonal antibody and measuring the amount of Mcm5 that binds to the first monoclonal antibody and/or the second monoclonal antibody. The invention further relates to kits that can be used in the methods.
Type:
Application
Filed:
December 21, 2021
Publication date:
August 18, 2022
Applicant:
ARQUER DIAGNOSTICS LIMITED
Inventors:
David Nicholas MILLER-JONES, Cheryl NYBERG, Ronald Alfred LASKEY, Kai STOEBER
Abstract: The present invention relates to methods for detecting the presence of Mcm5 in a subject, the method comprising preparing a sample from said subject by exposing the sample to a lysis buffer and performing an assay to determine the concentration of Mcm5 by exposing the sample to a first monoclonal antibody and/or a second monoclonal antibody and measuring the amount of Mcm5 that binds to the first monoclonal antibody and/or the second monoclonal antibody. The invention further relates to kits that can be used in the methods.
Type:
Grant
Filed:
June 1, 2016
Date of Patent:
July 19, 2022
Assignee:
ARQUER DIAGNOSTIC LIMITED
Inventors:
David Nicholas Miller-Jones, Cheryl Nyberg, Ronald Alfred Laskey, Kai Stoeber