Abstract: Compounds of Formula I, wherein R1—R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are also described.
Type:
Application
Filed:
September 27, 2006
Publication date:
February 15, 2007
Applicants:
Wyeth, ArQule
Inventors:
Anthony Kreft, Derek Cole, Kevin Woller, Joseph Stock, Kristina Kutterer, Dennis Kubrak, Charles Mann, William Moore, David Casebier
Inventors:
Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier