Abstract: The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
Type:
Grant
Filed:
November 30, 2018
Date of Patent:
November 7, 2023
Assignee:
Arrakis Therapeutics, Inc.
Inventors:
Gnanasambandam Kumaravel, Jennifer C. Petter, Jonathan Craig Blain, Donovan Noel Chin, Chao Fang, Herschel Mukherjee, Neil Kubica