Patents Assigned to Array Biopharma Inc.
  • Process for the reduction of cyano-substituted sulfones to aminoalkylene-substituted sulfones
    Patent number: 6462238
    Abstract: Disclosed is a process for selectively reducing a nitrile containing organic compound that also contains a sulfone moiety, the nitrile being reduced to a primary amine.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: October 8, 2002
    Assignee: Array BioPharma, Inc.
    Inventors: Jack (ChanKou) Hwang, Eugene Tarlton, Anthony D. Piscopio
  • Compounds which inhibit tryptase activity
    Patent number: 6362216
    Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.
    Type: Grant
    Filed: May 3, 2000
    Date of Patent: March 26, 2002
    Assignee: Array Biopharma Inc.
    Inventors: Laurence E. Burgess, James P. Rizzi
  • Sulfonamide bridging compounds that inhibit tryptase activity
    Patent number: 6221914
    Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: April 24, 2001
    Assignee: Array Biopharma Inc.
    Inventors: Laurence E. Burgess, James P. Rizzi