Abstract: A clamping system including a cover plate with an underside having at least one step, and a bottom plate having a base connected to a first side, a second side, a third side, and a fourth side. The bottom plate also has a well for receiving a reactor plate. The clamping system further includes a compression skirt positioned between the cover plate and the bottom plate, with the compression skirt having a first side, a second side, a third side, and a fourth side corresponding to the first, second, third, and fourth sides of the bottom plate, respectively. Additionally, the clamping system includes a first and a second upper latch assembly for clamping the cover plate to the compression skirt, and a first and a second lower latch assembly for clamping the compression skirt to the bottom plate.

Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.

Abstract: The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell activation. Also encompassed by the invention are formulations comprising the noted compounds, processes for preparing such compounds and methods for treating or preventing an inflammatory disease.