Patents Assigned to Arris Pharmaceuticals
  • Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
    Patent number: 5976858
    Abstract: Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: November 2, 1999
    Assignee: Arris Pharmaceuticals
    Inventors: James T. Palmer, David Rasnick, Jeffrey Lee Klaus