Patents Assigned to ARSENAL BIOSCIENCES, INC.
  • Systems targeting PSMA and CA9
    Patent number: 12257304
    Abstract: Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Grant
    Filed: March 1, 2024
    Date of Patent: March 25, 2025
    Assignee: Arsenal Biosciences, Inc.
    Inventors: Angela Boroughs, Levi Gray-Rupp, Samuel A. Williams, Zhen Jian Zhou, Matthew Drever, Duy Nguyen, Amy-Jo Casbon, Anzhi Yao, Thomas Gardner
  • Immune cells having co-expressed shRNAS and logic gate systems
    Patent number: 12037407
    Abstract: Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.
    Type: Grant
    Filed: May 3, 2023
    Date of Patent: July 16, 2024
    Assignee: Arsenal Biosciences, Inc.
    Inventors: Jasper Williams, Michelle Nguyen, Anzhi Yao, Stephen Santoro, Aaron Cooper, John Gagnon, Adam Litterman, Omar Khan, Natalie Bezman, Katherine Harris, Harbani Kaur Malik Chaudhry, Nicole Allen
  • Safe harbor loci
    Patent number: 11761004
    Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: September 19, 2023
    Assignee: ARSENAL BIOSCIENCES, INC.
    Inventors: Xinying Zheng, Brendan Galvin, Somya Khare, Aaron Cooper, Michelle Nguyen, Anzhi Yao
  • Safe harbor loci
    Patent number: 11332744
    Abstract: Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: May 17, 2022
    Assignee: ARSENAL BIOSCIENCES, INC.
    Inventors: Xinying Zheng, Brendan Galvin, Somya Khare, Aaron Cooper, Michelle Nguyen, Anzhi Yao