Abstract: In a combined container-syringe, a rubber packing that covers the distal end opening of a cylinder at a fitting hole of a cylindrical tip in an air tight and liquid tight manner, and in which is formed a through hole that brings a communication hole formed in a lure tip and the inside of the cylinder into communication, and a rubber member that is inserted from the distal end side of the communication hole and blocks the through hole are provided, and the rubber packing is formed with an elastic body that is corrosion resistant to the liquid medicament. With this combined container-syringe, in addition to being able to store it for a long period without deteriorating the liquid medicament, it is possible to observe well the liquid medicament or blood that flows to the cylindrical tip, and moreover preventing leftover liquid medicament after injection becomes possible.

Abstract: A heterologous protein is produced by a method in which yeast-type host cells are prepared, which, in addition to the at least one endogenous homologous DNA sequence coding for a first calnexin, includes at least one recombinant DNA sequence coding for the protein and at least one additional recombinant DNA sequence coding for at least one second calnexin. The protein in the host cell represents a heterologous secretable protein. The host cells are induced to express the heterologous protein via the at least one sequence coding for the protein and to overexpress calnexins by the at least one additional sequence coding for the at least one second calnexin. The host cells are then induced to secrete the heterologous protein. The secreted heterologous protein is then separated off.

Abstract: A combined container-syringe includes a body that has an outer tube to be filled with a drug solution. A cylindrical tip is attached to a front end portion of the outer tube and to a front end portion of which an injection needle is attached. A cylindrical safety device is attached on an outer circumferential surface of the outer tube in a freely sliding manner. A first retaining member fixes the safety device in a disengageable manner at a first position where the safety device is separated from the injection needle. A second retaining member fixes the safety device at a second position where the safety device covers the injection needle. A biasing member biases the safety device in the direction from the first position to the second position. A latch releasing member releases the engagement by the first retaining member.

Abstract: A combined container-syringe includes: a cartridge; a needle hub having a base portion, a cylinder portion inside which a bypass chamber is formed, and a needle attachment portion inside which an introducing hole communicated with an injection needle is formed; a front stopper; a rear stopper; and a plunger rod connected to the rear stopper, in which: a bypass groove communicated with the introducing hole, and an annular groove connected to the bypass groove are formed on an inner circumferential surface of the bypass chamber; an air-bubble introducing groove is formed on an outer circumferential surface of the front stopper, the air-bubble introducing groove extending from a rear end surface of the front stopper toward a front end; and the air-bubble introducing groove and the annular groove are communicated with each other in a state where a part of the front stopper is disposed in the cartridge.

Abstract: This combined container-syringe comprising a glass cylinder which can be pre-filled with a drug, an cylindrical tip provided at an exterior portion of an anterior end of the syringe, and a finger grip provided at an exterior portion of an posterior end of the syringe, and a drug is pre-filled therein and sealed by a stopper. Furthermore, an impact absorption part is provided around the exterior portion of the cylindrical tip and a diameter of the impact absorption part is greater than an outer diameter of a fitting part to the cylinder of the cylindrical tip.

Abstract: The present invention relates to a combined container-syringe including: a cylindrical cylinder filled with a drug solution; a cylindrical tip provided at the cylinder; an injection needle mounted on the cylindrical tip; a finger grip provided on the cylinder; a cylindrical-shaped safety device that is mounted in a slidable manner on the outer periphery of the cylinder and covers the injection needle when it has moved in the front end direction; a retaining member that selectively engages the safety device at a first position that is away from the injection needle and a second position that covers the injection needle; and a coil spring that biases the safety device in the direction of the second position. According to the present invention, it is possible to reliably cover the injection needle by causing the safety device to move with respect to the syringe body and so possible to ensure safety.

Abstract: Microspheres to be implanted into a patient are metered and mixed with fluids, cells, or tissues withdrawn from the patient's own body, and reinserted into the patient's body to achieve augmentation, repair or other treatment of the patient's tissue.

Abstract: An injection apparatus including a first body portion with a first stopper and a second body portion with a second stopper is disclosed. The first body portion is capable of receiving a first material in a portion of the first body portion distal to the first stopper. The second body portion is fluidly coupled to the first body portion, and is capable of receiving the first material in a portion of the second body portion disposed proximally of the second stopper. The second body portion is also capable of receiving a second material in a portion of the second body portion disposed distally of the second stopper.

Abstract: The present invention provides a combined container-syringe comprising a syringe body containing a cylindrical-shaped cylinder; a cylindrical tip provided at the anterior end of said cylinder; a finger grip fitted to the posterior end of the cylinder; an injection needle fitted to the cylindrical tip; and a protector covering said injection needle. In addition, the present invention provides a method of assembling a combined container-syringe characterized in comprising an injection needle assembly preparatory process of preparing an injection needle assembly; a detection process of detecting the position of the cutting surface; a mark display process of indicating the detected position of the cutting surface; an aligning process of aligning the positions of the mark and a scale display provided on the exterior portion of the cylinder, on the circumference of the cylinder; and a fitting process of fitting the injection needle assembly to the cylindrical tip.

Abstract: An elongated syringe for administering a substance to a patient includes an elongated syringe chamber that may be inserted into a duct of a patient without unwantingly injuring the patient, a needle extending from the distal end of the syringe chamber, and a plunger rod extending from the proximal end of the syringe chamber. The syringe chamber may be flexible to accommodate curvatures of the duct of the patient. The syringe chamber includes a plurality of chamber compartments that will contain a fluid. At least one of the chamber compartments contains a fluid that is administered to a patient. The syringe chamber may include a driving piston located between two or more chamber compartments. The needle of the syringe may be a component of a transition-bore needle apparatus to facilitate delivery of a relatively viscous fluid from the syringe. The needle may also be flared at its proximal end so that the diameter of the proximal end of the needle is greater than the diameter of the distal end of the needle.

Abstract: An elongated syringe for administering a substance to a patient includes an elongated syringe chamber that may be inserted into a duct of a patient without unwantingly injuring the patient, a needle extending from the distal end of the syringe chamber, and a plunger rod extending from the proximal end of the syringe chamber. The syringe chamber may be flexible to accommodate curvatures of the duct of the patient. The syringe chamber includes a plurality of chamber compartments that will contain a fluid. At least one of the chamber compartments contains a fluid that is administered to a patient. The syringe chamber may include a driving piston located between two or more chamber compartments. The needle of the syringe may be a component of a transition-bore needle apparatus to facilitate delivery of a relatively viscous fluid from the syringe. The needle may also be flared at its proximal end so that the diameter of the proximal end of the needle is greater than the diameter of the distal end of the needle.

Abstract: An injection apparatus includes components that facilitate injection of relatively viscous materials into a patient. An injection apparatus may include a transition-bore needle apparatus, which has a proximal end, a distal end, and a lumen extending from the proximal end to the distal end, in which the diameter of the proximal end is greater than the diameter of the distal end. An injection apparatus may include a hand-held injection facilitation apparatus, which may be coupled to a syringe. The hand-held injection facilitation apparatus can include a pivot arm and a body with a rod disposed within the body and coupled to the pivot arm. Movement of the pivot arm results in a proximal or distal movement of the rod within the body to effectively cause material to be expelled from the syringe. An injection apparatus may include a transition-bore needle apparatus and a hand-held injection facilitation apparatus in combination.

Abstract: A surgical device for expanding and viewing tissue is disclosed. The surgical device includes a handle, an insertion probe, and at least one window disposed within the insertion probe. The handle has a proximal end and a distal end, and the handle is sized and shaped to be held by a surgeon. The insertion probe has a proximal end, a distal end, and a longitudinal axis extending between the proximal end and the distal end. The proximal end of the insertion probe is removably attached to the distal end of the handle. The window extends along a length of the longitudinal axis, and has an opening that is sufficient in size to allow tissue to prolapse through the window and into the insertion probe.

Abstract: The present invention provides a combined container-syringe comprising a syringe body containing a cylindrical-shaped cylinder; a cylindrical tip provided at the anterior end of said cylinder; a finger grip fitted to the posterior end of the cylinder; an injection needle fitted to the cylindrical tip; and a protector covering said injection needle. In addition, the present invention provides a method of assembling a combined container-syringe characterized in comprising an injection needle assembly preparatory process of preparing an injection needle assembly; a detection process of detecting the position of the cutting surface; a mark display process of indicating the detected position of the cutting surface; an aligning process of aligning the positions of the mark and a scale display provided on the exterior portion of the cylinder, on the circumference of the cylinder; and a fitting process of fitting the injection needle assembly to the cylindrical tip.

Abstract: Behind a slidable end sealing member 3c, there is provided a liquid-absorbing element M which has a liquid-holding function so as to absorb and hold a liquid L flowing out from the end sealing member 3c when the end sealing member passes over a bypass portion 6. As this liquid-absorbent element M, such as a disk-like element D and a cylindrical element R, are typically impregnated with a water-holding and liquid-absorbing accelerator to enhance a leak preventing effect and with an antimicrobial active agent to enhance hygiene.

Abstract: The present invention relates to a prefill syringe in which the space provided at the joining area between a cap or protector and a needle holder can be covered by an inexpensive material and a simple method, without interrupting the flow of the production process. In this prefill syringe, a cap 15 or a protector is attached to a needle holder 11 provided to one end of cartridge 10, and a cylindrical member 20 formed of an elastic material is externally engaged to span the needle holder and cap or protector so as to cover the joining area A between the needle holder and the cap, or the joining area between the needle holder and the protector. Further, one or more ring-shaped projections which contact the outer peripheral surface of the needle holder and the outer peripheral surface of the cap are formed to the inner periphery of the cylindrical member.

Abstract: A syringe outer cylinder is split into a front chamber outer cylinder and a rear chamber outer cylinder. Powdered medicine is sealed in a sterilized state in the front chamber outer cylinder. Liquid medicine is sealed in a sterilized state in the rear chamber outer cylinder. Thereafter, the front chamber outer cylinder is coupled to the rear chamber outer cylinder with a coupling component, and the dual chamber prefillable syringe is assembled. Therefore, sealing of powdered medicine and liquid medicine can occur in parallel.