Abstract: The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
January 17, 2023
Assignee:
Nimbus Artemis, Inc.
Inventors:
Silvana Marcel Leit de Moradei, Eric Therrien
Abstract: The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.
Type:
Grant
Filed:
November 15, 2019
Date of Patent:
November 8, 2022
Assignee:
Nimbus Artemis, Inc.
Inventors:
Silvana Marcel Leit de Moradei, Kevin Kreutter, H. James Harwood, Eric Therrien
Abstract: An active oxygen scavenger comprising as an active ingredient a pterin derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are independently a hydrogen atom, an alkyl group of 1 to 4 carbon atoms, or an acyl group of the formula R.sup.3 --CO--, R.sup.3 is an alkyl group of 1 to 4 carbon atoms, X is a formyl group or hydroxymethyl group, A is a group of the formula (Ia): ##STR2## and n is 0 or an integer of 1 or more, with the proviso that when X is a hydroxymethyl group, n is 0, or when n is an integer of 1 or more, each of R.sup.1 and R.sup.2 is a hydrogen atoms, and X is a formyl group, or a cyclic compound thereof, or a salt thereof is disclosed.
Type:
Grant
Filed:
March 31, 1998
Date of Patent:
December 19, 2000
Assignee:
Artemis, Inc.
Inventors:
Toshiyuki Arai, Keisuke Makino, Kenjiro Mori